Oncogenes and Tumor Suppressor Genes Flashcards by Cyle Rogotzke

Q

Bcl-2

A

follicular and undifferentiated lymphomas

anti-apoptotic

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Q

BRAF

A

Melanoma

Serine/threonine kinase

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Q

c-kit

A

Gastrointestinal stromal tumor

Cytokine receptor for stem cell factor

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Q

C-myc

A

Burkitt lymphoma

Transcription factor

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Q

HER2/neu (c-erbB2)

A

Breast, ovarian, and gastric carcinomas

Tyrosine kinase in control of epithelial growth and differentiation

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Q

L-myc

A

Lung tumor

Transcription factor

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Q

N-myc

A

Neuroblastoma

Transcription factor

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Q

ras

A

Colon cancer, lung cancer, pancreatic cancer

GTPase

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Q

ret

A

MEN 2a and 2B

Tyrosine kinase

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Q

APC

A

colorectal cancer (associated with FAP)

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Q

BRCA1 BRCA2

A

breast and ovarian cancer

DNA repair protein

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Q

CPD4/SMAD4

A

Pancreatic cancer

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Q

DCC

A

colon cancer

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Q

NF1

A

Neurofibromatosis type 1

RAS GTPase activating protein (neurofibromin)

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Q

NF2

A

Neurofibromatosis type 2

Merlin schwannomin protein

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Q

P16

A

melanoma

Cyclin dependent kinase inhibitor 2A

Q

p53

A

most human cancers, li-fraumeni syndrome

transcription factor for p21
Blocks G1 to S phase

Q

PTEN

A

Breast cancer, prostate cancer, endometrial cancer

Q

Rb

A

Retinoblastoma, osteosarcoma

Inhibits E2F, blocks G1 to S phase

Q

TSC1 and TSC2

A

Tuberous sclerosis

1=hamartin
2=tuberin

Q

VHL

A

von hippel lindau disease

Inhibits hypoxia inducible factor

Q

BCR-ABL

A

CML, ALL

Tyrosine Kinase