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Step 1 Fast Facts > Immuno Fast Facts > Flashcards

Immuno Fast Facts Flashcards

0
Q

B27 HLA subtype association

A 
PAIR
Psoriatic arthritis 
Ankylosing spondylitis 
Inflammatory bowel disease
Reactive arthritis
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1
Q

A3 HLA subtype association

A

Hemochromatosis

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2
Q

DQ2/DQ8 HLA subtype association

A

Celiac disease

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3
Q

DR2 HLA subtype association

A

MS, hay fever, SLE, goodpasture

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4
Q

DR3 HLA subtype association

A

Type 1 diabetes, SLE, Graves’ disease

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5
Q

DR4 HLA subtype association

A

Rheumatoid arthritis, type 1 diabetes

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6
Q

DR5 HLA subtype association

A

Pernicious anemia leading to B12 deficiency

Hashimoto thyroiditis

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7
Q

Il-1

A

Causes fever, acute inflammation
released from macrophages
Activates endothelium to express adhesion molecules
Induces chemokine secretion to recruit leukocytes
indirectly promotes angiogenesis through incraesed VEGF production

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8
Q

IL-6

A

Released from macrophages and TH2 cells

causes fever and stimulates production of acute phase proteins

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9
Q

IL-8

A

Major chemotactic factor for neutrophils

Secreted by macrophages

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10
Q

IL-12

A

Induces differention of T cells into Th1 cells
Activates NK cells
Secreted by macrophages and B cells

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11
Q

TNF-a

A

Secreted by macrophages
Mediates septic shock
Activates endothelium
Causes luekocyte recruitment, vascular leak

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12
Q

IL-2

A

Secreted by all T cells
Secreted by All T cells
Stimulates growth of helper, cytotoxic, and regulatory T cells
Monocyte and NK cell activation
Increases activity of NK cells leading to anti tumor effects
Used in metastatic melanoma and renal cell carcinoma

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13
Q

IL-3

A

Secreted by all T cells
Supports growth and differentiation of bone marrow stem cells
Functions like GM-CSF

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14
Q

IFN-y

A

Secreted from TH1 cells
Has antiviral and Antitumor properties
Activates NK cells to kill virus infected cells
Increases MHC expression and Ag presentation in all cells
Indirectly increases angiogenesis by increasing VEGF expression

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15
Q

IL-4

A

Secreted from TH2 cells
Enhances switching of IgE and IgG
Promotes growth of B cells

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16
Q

IL-5

A

Secreted from Th2 cells
Enhances class switching to IgA
Stimulates growth and differentiation of B cells and eosinophils

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17
Q

IL-10

A

Secreted from TH2 cells and Treg cells
Modulates inflammatory response
Inhibits actions of activated T cells and Th1

18
Q

CD56

A

Unique marker for NK cells

19
Q

CD21

A

Receptor for EBV on B cells

20
Q

CD16

A

On NK cells Binds Fc of IgG

21
Q

CD14

A

Endotoxin receptor on Macrophages

22
Q

Ach receptor Ab

A

Myasthenia gravis

23
Q

Anti Basement membrane Ab

A

Goodpasture syndrome

24
Q

Anti cardiolipin Ab

A

SLE, antiphospholipid syndrome

25
Q

Anticentromere Ab

A

limited scleroderma (CREST)

26
Q

Antidesmoglein Ab

A

Pemphigus vulgaris

27
Q

Anti-ds DNA, anti-Smith Ab

A

SLE

28
Q

Anti-glutamate decarboxylase Ab

A

Type I diabetes mellitus

29
Q

Anti-hemidesmosome Ab

A

Bullous pemphigoid

30
Q

Antihistone Ab

A

Drug induced lupus

31
Q

Anti-Jo-1, anti SRP, anti-Mi-2 Ab

A

Polymyositis , dermatomyositis

32
Q

Antimitochondrial Ab

A

Primary biliary cirrhosis

33
Q

Antinuclear Ab

A

SLE, nonspecific

34
Q

Ant-Scl 70 (anti-DNA topoisomerase I) ab

A

Scleroderma diffuse

35
Q

Anti-smooth muscle Ab

A

Autoimmune hepatitis

36
Q

Anti-SSA, anti-SSB (anti-Ro, anti-La) Ab

A

Sjogren syndrome

37
Q

Anti-TSH receptor Ab

A

Graves Disease

38
Q

Anti-U1 RNP (ribonucleoprotein) Ab

A

Mixed connective tissue disease

39
Q

c-Anca Ab

A

Wegeners granuomatosis

40
Q

IgA antiendomysial, IgA anti-tissue transglutaminase Ab

A

Celiac disease

41
Q

p-ANCA

A

Microscopic polyangiitis, Churg-strauss syndrome

42
Q

Ab, most commonly IgM, specific to IgG Fc region, anti CCP

A

Rheumatoid arthritis

Step 1 Fast Facts (12 decks)

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