Immuno Fast Facts Flashcards
B27 HLA subtype association
PAIR Psoriatic arthritis Ankylosing spondylitis Inflammatory bowel disease Reactive arthritis
A3 HLA subtype association
Hemochromatosis
DQ2/DQ8 HLA subtype association
Celiac disease
DR2 HLA subtype association
MS, hay fever, SLE, goodpasture
DR3 HLA subtype association
Type 1 diabetes, SLE, Graves’ disease
DR4 HLA subtype association
Rheumatoid arthritis, type 1 diabetes
DR5 HLA subtype association
Pernicious anemia leading to B12 deficiency
Hashimoto thyroiditis
Il-1
Causes fever, acute inflammation
released from macrophages
Activates endothelium to express adhesion molecules
Induces chemokine secretion to recruit leukocytes
indirectly promotes angiogenesis through incraesed VEGF production
IL-6
Released from macrophages and TH2 cells
causes fever and stimulates production of acute phase proteins
IL-8
Major chemotactic factor for neutrophils
Secreted by macrophages
IL-12
Induces differention of T cells into Th1 cells
Activates NK cells
Secreted by macrophages and B cells
TNF-a
Secreted by macrophages
Mediates septic shock
Activates endothelium
Causes luekocyte recruitment, vascular leak
IL-2
Secreted by all T cells
Secreted by All T cells
Stimulates growth of helper, cytotoxic, and regulatory T cells
Monocyte and NK cell activation
Increases activity of NK cells leading to anti tumor effects
Used in metastatic melanoma and renal cell carcinoma
IL-3
Secreted by all T cells
Supports growth and differentiation of bone marrow stem cells
Functions like GM-CSF
IFN-y
Secreted from TH1 cells
Has antiviral and Antitumor properties
Activates NK cells to kill virus infected cells
Increases MHC expression and Ag presentation in all cells
Indirectly increases angiogenesis by increasing VEGF expression
IL-4
Secreted from TH2 cells
Enhances switching of IgE and IgG
Promotes growth of B cells
IL-5
Secreted from Th2 cells
Enhances class switching to IgA
Stimulates growth and differentiation of B cells and eosinophils
IL-10
Secreted from TH2 cells and Treg cells
Modulates inflammatory response
Inhibits actions of activated T cells and Th1
CD56
Unique marker for NK cells
CD21
Receptor for EBV on B cells
CD16
On NK cells Binds Fc of IgG
CD14
Endotoxin receptor on Macrophages
Ach receptor Ab
Myasthenia gravis
Anti Basement membrane Ab
Goodpasture syndrome
