Tumor Suppressor Genes

Question 1

APC

Answer 1

Gene product: protein that regulates B-catenin

Associated tumor: Colorectal cancer; associated with FAP

Question 2

BRCA1/2

Answer 2

Gene product: DNA repair protein

Associated tumor: Breast and Ovarian cancer

Question 3

CPD4/SMAD4

Answer 3

Gene product: DPC

Associated tumor: Pancreatic cancer

Question 4

DCC

Answer 4

Gene product: DCC

Associated tumor: Colon cancer

Question 5

MEN1

Answer 5

Associated tumor: MEN1

Question 6

NF1

Answer 6

Gene product: RAS GTPase activating protein (neurofibromin)

Associated tumor: NF1

Question 7

NF2

Answer 7

Gene product: Merlin (shwannomin) protein

Associated tumor: NF2

Question 8

p16

Answer 8

Gene product: Cdk inhibitor 2A

Associated tumor: Melanin

Question 9

p53

Answer 9

Gene product: Transcription factor for p21; blocks G1–>S

Associated tumor: Most human cancers, Li-Fraumeni syndrome

Question 10

PTEN

Answer 10

Associated tumor: Prostate cancer, Tit (breast) cancer, ENdometrial cancer

Question 11

Rb

Answer 11

Gene product: Inhibits E2F; blocks G1–>S

Associated tumor: Retinoblastoma, Osteosarcoma

Question 12

TSC1

Answer 12

Gene product: Hamartin protein

Associated tumor: Tuberous sclerosis

Question 13

TSC2

Answer 13

Gene product: Tuberin protein

Associated tumor: Tuberous sclerosis

Question 14

VHL

Answer 14

Gene product: inhibits hypoxia-inducible factor 1a

Associated tumor: vHL dz

Question 15

WT1/2

Answer 15

Associated tumor: Wilm’s tumor (nephroblastoma)

Question 16

Psammoma bodies

Answer 16

• Papillary thyroid carcinoma
• Serous papillary cystadenocarcinoma of ovary
• Meningioma
• Malignant mesothelioma