Paraneoplastic syndromes Flashcards
1
Q
1,25 (OH)2 D3
A
Hodgkin lymphoma, some NHL
–> Hypercalcemia
2
Q
ACTH
A
Small cell lung carcinoma
–> Cushing syndrome
3
Q
ADH
A
Small cell lung carcinoma, intracranial neoplasms
–> SIADH –> hyponatremia and decr. serum osmolarity
4
Q
Abs against pre-synaptic Ca2+ channels at NMJ
A
Small cell lung carcinoma
–> Lambert-Eaton Myasthenic syndrome –> muscle weakness that improves with repeated use
5
Q
EPO
A
Renal cell carcinoma, Hemangioblastoma, Hepatocellular carcinoma, Pheochromocytoma, Leiomyoma, Thymoma
–> Polycythemia
6
Q
PTHrP
A
Squamous cell lung carcinoma, Renal cell carcinoma, Breast cancer, Squamous cell carcinoma of head and neck
–> Hypercalcemia
7
Q
Osteolytic factors
A
Myeloma
–> Hypercalcemia
8
Q
Incr. nuclei acid turnover
A
Leukemias, Lymphomas
–> Hyperuricemia –> Gout, Urate nephropathy
