Oncogenes

Question 1

BCR-ABL

Answer 1

Gene product: tyrosine kinase

Associated tumor: CML, ALL

Question 2

bcl-2

Answer 2

Gene product: anti-apoptotic molecule; inhibits Apaf-1

Associated tumor: Follicular and undifferentiated lymphomas

Question 3

BRAF

Answer 3

Gene product: Serine/Threonine kinase

Associated tumor: Melanoma

Question 4

c-kit

Answer 4

Gene product: Cytokine receptor for stem cell factor

Associated tumor: GI stromal tumor

Question 5

c-myc

Answer 5

Gene product: Transcription factor

Associated tumor: Burkitt lymphoma

Question 6

Her2/neu (c-erbB2)

Answer 6

Gene product: Tyrosine kiase

Associated tumor: Breast, Ovarian, Gastric carcinomas

Question 7

L-myc

Answer 7

Gene product: Transcription factor

Associated tumor: Lung tumor

Question 8

N-myc

Answer 8

Gene product: Transcription factor

Associated tumor: Neuroblastoma

Question 9

Ras

Answer 9

Gene product: GTPase

Associated tumor: Colon, Lung, Pancreatic cancers

Question 10

Ret

Answer 10

Gene product: Tyrosine kinase

Associated tumor: MEN 2A, 2B