Drug Side Effects Flashcards
Coronary vasospasm
- Cocaine
- Amphetamines
- Methamphetamines
- Triptans: sumatriptan
- Ergotamines
Anticholinergic
- Atropine: prototypical anticholinergic
- TCAs
- H1 blockers: diphenhydramine
- Digoxin
- Low Potency Neuroleptics
- Amantadine
- Promethazine
- dont give to PTs with potential for confusion/delirium or PTs with BPH, ileus problems or constipationo
Cutaneous flushing
- Vancomycin: red man syndrome
- Niacin
- Adenosine: potent vasodilation
- Dihydropyridine CCBs: via smooth muscle relaxation
Dilated cardiomyopathy
- Doxorubicin
- Daunorubicin
Torsades de pointes
Drugs that prolong QT interval:
- Class III K+ channel blockers
- Class IA Na+ channel blockers
- Macrolides
- Haloperidol
- Chloriquine
- Protease inhibitors
*Tx: push IV magnesium
Agranulocytosis
- Clozapine
- Carbamazepine
- Colchicine
- PTU
- Methimazole
- Dapsone
Aplastic anemia
- Chloramphenicol
- Benzene
- NSAIDs
- PTU
- Methimazole
Thrombocytopenia
- Heparin
- H2 blockers: -itidine
Gray baby syndrome
Chloramphenicol
Hemolysis in G6PD patients
- INH
- Sulfonamides
- Primaquine
- High dose aspirin
- Ibuprofen
- Nitrofurantioin- UTI drug
- Dapsone
- Fava beans
- Naphthalene
Thrombosis
Oral Contraceptives
-Esp. If PT is a smoker >35 yrs of age
Pulmonary fibrosis
- Bleomycin
- Busulfan
- Amiodarone: PFTs, LFTs, TFTs
Cough
ACE inhibitors
-d/t excess bradykinin
Focal to massive hepatic necrosis
- Halothane
- Acetaminophen
- Valproic acid
- Amanita phalloides (mushroom toxin)
Pseudomembranous colitis
- Clindamycin
- Ampicillin
- Any antibiotic
Adrenocortical insufficiency
Withdrawal of corticosteroids in a PT dependent on exogenous steroids
Gynecomastia
- Spironolactone
- Digitalis
- Cimetidine
- Chronic alcohol use
- Estrogens
- Ketoconazole
- Marijuana
Hot flashes
- Tamoxifen
- Clomiphene
Hypothyroidism
- Amiodarone
- Lithium
- Sulfonamides
Gingival hyperplasia
- Phenytoin
- Verapamil
Gout
- Furosemide
- Thiazides
- Niacin
- Cyclosporine
- Pyrazinamide
Osteoporosis
- Corticosteroids >3 mo
- Heparin
Photosensitivity
- Sulfonamides
- Amiodarone
- Tetracycline
Stevens-Johnson syndrome
- Seizure drugs: Ethosuximide, Carbamazepine, Lamotrigine, Phenytoin, Phenobarbital
- Sulfa drugs
- Penicillin
- Allopurinol
Drug-induced SLE
- Sulfonamides
- Hydralazine
- INH
- Phenytoin
- Procainamide
Tendon rupture/cartilage damage
Fluroquinolones
Fanconi syndrome
Proximal tubular defect
- Expired tetracycline
- Heavy metal exposure
Also associated with Wilson’s disease
Interstitial nephritis
- Methicillin
- NSAIDs
- Furosemide
Dizziness, nausea, headache, vision changes, tinnitus
- Quinidine: Class IA anti-arrhythmic
- Quinine
Nephrogenic diabetes insipidus
- Lithium
- Demeclocycline
*Tx: HCTZ
Seizures
- Bupropion
- Imipenem/Cilastatin
- INH
- Tramadol
- Metoclopramide
- Alcohol withdrawal
- Benzo withdrawal
Tardive dyskinesia
High potency typical antipsychotics
Disulfiram-like reaction
- Metronidazole
- certain Cephalosporins
- Procarbazine
- First generation sulfonylureas
- Disulfiram
Nephrotoxicity + Neurotoxicity
- Aminoglycosides
- Cisplatin
- Polymyxins
Nephrotoxicity + Ototoxicity
- Aminoglycosides
- Vancomycin
- Loop diuretics
- Cisplatin
Hepatitis
INH
Hemorrhagic cystitis
- Cyclophosphamide
- Ifosfamide
CYP450 inducers
- Phenytoin
- Rifampin
- St. John’s wort
- Barbiturates
- Griseofulvin
- Carbamazepine
CYP450 inhibitors
- Cimetidine
- Ritonavir
- Amiodarone
- Ciprofloxacin
- Ketoconazole
- Acute alcohol use
- Macrolides
- INH
- Grapefruit juice
- Omeprazole
- Sulfonamides
