Drug Side Effects Flashcards
0
Q
Coronary vasospasm
A
- Cocaine
- Amphetamines
- Methamphetamines
- Triptans: sumatriptan
- Ergotamines
1
Q
Anticholinergic
A
- Atropine: prototypical anticholinergic
- TCAs
- H1 blockers: diphenhydramine
- Digoxin
- Low Potency Neuroleptics
- Amantadine
- Promethazine
- dont give to PTs with potential for confusion/delirium or PTs with BPH, ileus problems or constipationo
2
Q
Cutaneous flushing
A
- Vancomycin: red man syndrome
- Niacin
- Adenosine: potent vasodilation
- Dihydropyridine CCBs: via smooth muscle relaxation
3
Q
Dilated cardiomyopathy
A
- Doxorubicin
- Daunorubicin
4
Q
Torsades de pointes
A
Drugs that prolong QT interval:
- Class III K+ channel blockers
- Class IA Na+ channel blockers
- Macrolides
- Haloperidol
- Chloriquine
- Protease inhibitors
*Tx: push IV magnesium
5
Q
Agranulocytosis
A
- Clozapine
- Carbamazepine
- Colchicine
- PTU
- Methimazole
- Dapsone
6
Q
Aplastic anemia
A
- Chloramphenicol
- Benzene
- NSAIDs
- PTU
- Methimazole
7
Q
Thrombocytopenia
A
- Heparin
- H2 blockers: -itidine
8
Q
Gray baby syndrome
A
Chloramphenicol
9
Q
Hemolysis in G6PD patients
A
- INH
- Sulfonamides
- Primaquine
- High dose aspirin
- Ibuprofen
- Nitrofurantioin- UTI drug
- Dapsone
- Fava beans
- Naphthalene
10
Q
Thrombosis
A
Oral Contraceptives
-Esp. If PT is a smoker >35 yrs of age
11
Q
Pulmonary fibrosis
A
- Bleomycin
- Busulfan
- Amiodarone: PFTs, LFTs, TFTs
12
Q
Cough
A
ACE inhibitors
-d/t excess bradykinin
13
Q
Focal to massive hepatic necrosis
A
- Halothane
- Acetaminophen
- Valproic acid
- Amanita phalloides (mushroom toxin)
14
Q
Pseudomembranous colitis
A
- Clindamycin
- Ampicillin
- Any antibiotic
15
Q
Adrenocortical insufficiency
A
Withdrawal of corticosteroids in a PT dependent on exogenous steroids
16
Q
Gynecomastia
A
- Spironolactone
- Digitalis
- Cimetidine
- Chronic alcohol use
- Estrogens
- Ketoconazole
- Marijuana
17
Q
Hot flashes
A
- Tamoxifen
- Clomiphene
18
Q
Hypothyroidism
A
- Amiodarone
- Lithium
- Sulfonamides
19
Q
Gingival hyperplasia
A
- Phenytoin
- Verapamil
20
Q
Gout
A
- Furosemide
- Thiazides
- Niacin
- Cyclosporine
- Pyrazinamide
21
Q
Osteoporosis
A
- Corticosteroids >3 mo
- Heparin
22
Q
Photosensitivity
A
- Sulfonamides
- Amiodarone
- Tetracycline
23
Q
Stevens-Johnson syndrome
A
- Seizure drugs: Ethosuximide, Carbamazepine, Lamotrigine, Phenytoin, Phenobarbital
- Sulfa drugs
- Penicillin
- Allopurinol
24
Drug-induced SLE
- Sulfonamides
- Hydralazine
- INH
- Phenytoin
- Procainamide
25
Tendon rupture/cartilage damage
Fluroquinolones
26
Fanconi syndrome
Proximal tubular defect
- Expired tetracycline
- Heavy metal exposure
Also associated with Wilson's disease
27
Interstitial nephritis
- Methicillin
- NSAIDs
- Furosemide
28
Dizziness, nausea, headache, vision changes, tinnitus
- Quinidine: Class IA anti-arrhythmic
| - Quinine
29
Nephrogenic diabetes insipidus
- Lithium
- Demeclocycline
*Tx: HCTZ
30
Seizures
- Bupropion
- Imipenem/Cilastatin
- INH
- Tramadol
- Metoclopramide
- Alcohol withdrawal
- Benzo withdrawal
31
Tardive dyskinesia
High potency typical antipsychotics
32
Disulfiram-like reaction
- Metronidazole
- certain Cephalosporins
- Procarbazine
- First generation sulfonylureas
- Disulfiram
33
Nephrotoxicity + Neurotoxicity
- Aminoglycosides
- Cisplatin
- Polymyxins
34
Nephrotoxicity + Ototoxicity
- Aminoglycosides
- Vancomycin
- Loop diuretics
- Cisplatin
35
Hepatitis
INH
36
Hemorrhagic cystitis
- Cyclophosphamide
| - Ifosfamide
37
CYP450 inducers
- Phenytoin
- Rifampin
- St. John's wort
- Barbiturates
- Griseofulvin
- Carbamazepine
38
CYP450 inhibitors
- Cimetidine
- Ritonavir
- Amiodarone
- Ciprofloxacin
- Ketoconazole
- Acute alcohol use
- Macrolides
- INH
- Grapefruit juice
- Omeprazole
- Sulfonamides
