Tumor Markers pg 233

Question 1

Should tumor markers be used as the primary tool to diagnose cancer?

Answer 1

Hell no! Can be used to monitor tumor recurrence and response to therapy. Definitive Dx made only by biopsy.

Question 2

Alk Phos

Answer 2

Mets to bone
Liver cancer
Paget dz of bone
Seminoma (placental alk phos)

Question 3

Alpha Fetoprotein

Answer 3

HCC
Hepatoblastoma
Yolk Sac (Endodermal Sinus) Tumor
Testicular Cancer
Mixed Germ Cell Tumor (co-secreted w/ B-hCG)

Question 4

B-hCG

Answer 4

Hydatidiform Moles
Choriocarcinoma
Testicular Cancer

Question 5

CA-15-3/CA-27-9

Answer 5

Breast Cancer

Question 6

CA-19-9 + CEA

Answer 6

Pancreatic Cancer

Question 7

CA-125

Answer 7

Ovarian Cancer

Question 8

Calcitonin

Answer 8

Medullary Thyroid Carcinoma

Question 9

Carcinoembryonic Antigen (CEA)

Answer 9

Very non-specific
Colorectal Cancer
Pancreatic Cancer
Gastric, Breast, and Medullary Thyroid Carcinomas

Question 10

Used to follow prostate adenocarcinoma. Can also be elevated in BPH and prostatitis. Questionable risk/benefit for screening.

Answer 10

PSA

Question 11

Signifies neural crest origin.

Answer 11

S-100

Found in: melanomas, neural tumors, schwannomas, Langerhans cell histiocytosis, and astrocytomas)

Question 12

Tartrate-Resistant Acid Phosphatase (TRAP)

Answer 12

Hairy Cell Leukemia (B cell neoplasm)