Oncogenes pg 232 Flashcards
1
Q
Found in CML and ALL.
A
BCR-ABL=tyrosine kinase (tx w/ Imatinib)
2
Q
Follicular and Undifferentiated Lymphomas
A
bcl-2=inhibits apoptosis
3
Q
Melanoma
A
BRAF=serine/threonine kinase
4
Q
GIST
A
c-kit=cytokine receptor (for stem cell factor)
5
Q
Burkitt Lymphoma
A
c-myc=transcription factor
6
Q
Breast, Ovarian, and Gastric Carcinomas
A
HER2/neu (c-erbB2)=tyrosine kinase
7
Q
Small Cell Lung Cancer
A
L-myc=transcription factor
8
Q
Neuroblastoma
A
N-myc=transcription factor
Notes: MC location in Adrenals; Histology shows Homer-Wright pseudorosettes
9
Q
Colon, Lung, and Pancreatic Cancer
A
Ras=GTPase
10
Q
MEN2A and MEN2B
A
Ret=Tyrosine Kinase
11
Q
What kind of mutation causes Oncogenes to result in an increased cancer risk?
A
Gain of Function
12
Q
How many alleles must be damaged for an oncogene to cause problems?
A
ONE allele
