Rate-Limiting Enzymes pg 99

Question 1

Glycolysis

Answer 1

PFK-1
(+): AMP, Fructose-2,6-Bisphosphate
(-): ATP, Citrate

Question 2

Gluconeogenesis

Answer 2

Fructose-1,6-Bisphosphatase
(+): ATP, Acetyl-CoA
(-): AMP, Fructose-2,6-Bisphosphate

Question 3

TCA Cycle

Answer 3

Isocitrate Dehydrogenase
(+): ADP
(-): ATP, NADH

Question 4

Glycogenesis

Answer 4

Glycogen Synthase
(+): Glucose-6-Phosphate, Insulin, Cortisol
(-): Epinephrine, Glucagon

Question 5

Glycogenolysis

Answer 5

Glycogen Phosphorylase
(+): Epinephrine, Glucagon, AMP
(-): Glucose-6-Phosphate, Insulin, ATP

Question 6

HMP Shunt

Answer 6

G6PD
(+): NADP+
(-): NADPH

Question 7

De Novo Pyrimidine Synthesis

Answer 7

Carbamoyl Phosphate Synthetase II (CPSII)

Question 8

De Novo Purine Synthesis

Answer 8

Glutamine-Phosphoribosylpyrophosphate (PRPP) Amidotransferase
(-): AMP, IMP, GMP

Question 9

Urea Cycle

Answer 9

Carbamoyl Phosphate Synthetase I (CPSI)

(+): N-acetylglutamate

Question 10

Fatty Acid Synthesis

Answer 10

Acetyl-CoA Carboxylase
(+): Insulin, Citrate
(-): Glucagon, Palmitoyl-CoA

Question 11

Fatty Acid Oxidation

Answer 11

Carnitine Acyltransferase I

(-): Malonyl-CoA

Question 12

Ketogenesis

Answer 12

HMG-CoA Synthase

Question 13

Cholesterol Synthesis

Answer 13

HMG-CoA Reductase
(+): Insulin, Thyroxine
(-): Glucagon, Cholesterol