Tumor Immunolgy- Lecture 10/22/21 Flashcards
1
Q
Neoantigens
A
Produced by mutated proteins in different tumor cell clones
2
Q
Inappropriate expression
A
Some cells overexpress proteins, cause immune activation
3
Q
Oncogenes virus antigens
A
Virus encoded proteins presented on class I MHC
4
Q
Examples of oncofetal antigens (2)
A
Carcinoembryonic antigen
A-fetal protein
Markers of cancer
5
Q
Examples of tumor antigens (4)
A
- Neoantigens
- Inappropriate expression of cellular proteins
- Oncogenic viral antigen
- Oncofetal antigens
6
Q
NK cells role in killing cancer cells
A
Recognizes the lack of MHC molecules on cell surface
7
Q
IgG mediated destruction of tumor cells
A
By ADCP, ADCC, complement mediated lysis
8
Q
How do tumors evade immune system (3)
A
- Failure to express any tumor antigens
- Mutations in MHC genes or genes needed for antigen processing
- production of immunosuppressive proteins
- TGFB
- PD-L1
9
Q
Current immunotherapies for cancer (4)
A
- Passive immunotherapy
- Immunotoxins
- Checkpoint blockage
- CART
10
Q
Immunotoxins
A
Deliver toxin directly to tumor cells using cell specific antibody
11
Q
Checkpoint inhibition
A
Inhibiting CTLA and PD11 with antibodies
