T Lymphocyte Development-Lecture 10/6/21

Question 1

MHC

Answer 1

Protein expressed by all cells that allow them to display the peptide

Question 2

TCR structure

Answer 2

Made by VDJ recombination, looks a lot like B cells with a variable region and constant region

Question 3

Chains of a TCR

Answer 3

Vast majority have alpha and beta, some have gamma and delta

Question 4

CD3

Answer 4

Protein that is expressed on all T cells, important second messenger

Question 5

TCR interaction

Answer 5

Interacts with both MHC and Peptide, need bth to be present to bind tightly

Question 6

CD8

Answer 6

Expressed in T cells that interact with MHC class I molecules, known as killer T cells

Question 7

Killer T cells

Answer 7

Express CD8, recognize every uncleared cell in the body

Question 8

CD4

Answer 8

Expressed on T cells that recognize class II MHC (Antigen presenting cells), helper T cells

Question 9

Helper T cells

Answer 9

Express CD4, regulate the cytokines production

Question 10

DiGeorge syndrome

Answer 10

Little to know thymus, cannot make mature T cells and suffer from recurrent infections

Question 11

Early stages of T cell differentiation

Answer 11

Lymphoid progenitor moves to the thymus and differentiates to double neg thymocyte, does VDJ, become double positive

Question 12

Double negative thymocyte

Answer 12

First stage in development, does not express CD4 or CD8

Question 13

Double positive thymocyte

Answer 13

Second stage of development, expresses forth CD4 and CD8 (along with abTCR and CD3)

Question 14

Positive selection

Answer 14

Every cell that recognizes your MHC survives, everything else dies

Question 15

Negative selection

Answer 15

Last step in development, too strong an affinity for self peptides expressed by medullary epithelial cells and dendrites result in death