MHC And The Immune Response- Lecture 10/4/21

Question 1

C-reactive protein

Answer 1

Made in the liver, responds to inflammatory signals

Question 2

Chemotaxis

Answer 2

Migration of neutrophil along concentration of chemokine

Question 3

IL-8

Answer 3

Acts as a chemokine, signaling where infection is

Question 4

IFNalpha and IFNbeta

Answer 4

Anti-viral activity, make changes to host cells to prevent infection

Question 5

IL-10

Answer 5

An inhibitory cytokines that regulates immune response

Question 6

IL-12

Answer 6

Activates NK cells and promotes development of Th1 cells

Question 7

TCR genes

Answer 7

Use the dame VDJ recombination mechanism as BCR (RAG1 and RAG2), DO NOT undergo somatic hypermutation or Class switch

Question 8

MHC molecule

Answer 8

Presentation of peptide chains on the surface of cells

Question 9

Class I MHC molecules

Answer 9

Expressed by all uncleared cells

Question 10

Class II MHC molecules

Answer 10

Expressed by APC (antigen-presenting cells)

Question 11

APCs

Answer 11

Dendritic cells, Macrophages, B cells

Question 12

Structure of MHC class I

Answer 12

Alpha chain with peptide binding groove, B-microglobulin molecule

Question 13

Structure of MHC class II molecule

Answer 13

B chain and a chain, two form peptide binding groove

Question 14

HLA complex

Answer 14

Contain 6 genes HLA-A, HLA-B, HLA-C (class I) and HLA-DR, HLA-DP, and HLA-DQ (class II)

Question 15

MHC

Answer 15

Major histo compatibility complex, the more HLA alleles that an organ donor and recipient have in common, the more likely they are to survive

Question 16

Haplotypes

Answer 16

Inherit a set of 6 (3 class I and 3 class II) on one chromosome

Question 17

ANkylosing spondylitis (AS)

Answer 17

Associated with B27 allele, inflammatory disease of the vertebral joints