Tummors

Question 1

what is only expressed in tumor cells

Answer 1

Tumor-specific Ag

Question 2

what is expressed on normal cells

Answer 2

Tumor-associated Ag

Question 3

tumor antigens are presented by what

Answer 3

MHC class 1 to CD8+ T cells

Question 4

what has killed tumors in vitro

Answer 4

T lymphocytes
Antibodies
NK cells
macrophages

Question 5

what is the function of CTLs

Answer 5

perform surveillance

Question 6

what do NK cells target

Answer 6

IgG-coated tumor cells

Question 7

what cytokines aid nK cells

Answer 7

IL-2 and IL-12

Question 8

lacking what do not increase susceptibility to tumor development

Answer 8

T cells

Question 9

depletion of NK causes

Answer 9

increase in growth of experimental tumors

Question 10

macrophages secrete what

Answer 10

TNF-alpha that target tumor cells

Question 11

(Macrophages)

suppressive of what can

Answer 11

M2 suppressive MSCs can promote tumor growth

Question 12

lack of T cell recognition of tumor causes

Answer 12

inhibition of T cell activation and tumor escape

Question 13

what is active immunotherapy

Answer 13

augmented weakened host immune response

Question 14

Passive immunotherapy

Answer 14

administration of tumor specific antibodies and or T cells

Question 15

tumor cells exploit

Answer 15

normal pathways of negative immune regulation to evade immune response

Question 16

Anti-CTLA4

Anti-PD-1

Anti-PD-L1

Answer 16

Melanoma

Lung cancer

lung and merkel cancer

Question 17

blocking… causes….

Answer 17

PD-L1/PD-1

CTL activation and tumor cells are killed

Question 18

PD-L1/PD-1 causes

Answer 18

inhibition of CTL activation which causes tumor growth

Question 19

cytokine therapy…

Answer 19

stimulates T cell and NK cell activity

increase IL–2 and IFN-aplha

Question 20

downregulation of

Answer 20

antigens and MHC molecules induce tolerance to tumor antigens