Tummors Flashcards
what is only expressed in tumor cells
Tumor-specific Ag
what is expressed on normal cells
Tumor-associated Ag
tumor antigens are presented by what
MHC class 1 to CD8+ T cells
what has killed tumors in vitro
T lymphocytes
Antibodies
NK cells
macrophages
what is the function of CTLs
perform surveillance
what do NK cells target
IgG-coated tumor cells
what cytokines aid nK cells
IL-2 and IL-12
lacking what do not increase susceptibility to tumor development
T cells
depletion of NK causes
increase in growth of experimental tumors
macrophages secrete what
TNF-alpha that target tumor cells
(Macrophages)
suppressive of what can
M2 suppressive MSCs can promote tumor growth
lack of T cell recognition of tumor causes
inhibition of T cell activation and tumor escape
what is active immunotherapy
augmented weakened host immune response
Passive immunotherapy
administration of tumor specific antibodies and or T cells
tumor cells exploit
normal pathways of negative immune regulation to evade immune response
Anti-CTLA4
Anti-PD-1
Anti-PD-L1
Melanoma
Lung cancer
lung and merkel cancer
blocking… causes….
PD-L1/PD-1
CTL activation and tumor cells are killed
PD-L1/PD-1 causes
inhibition of CTL activation which causes tumor growth
cytokine therapy…
stimulates T cell and NK cell activity
increase IL–2 and IFN-aplha
downregulation of
antigens and MHC molecules induce tolerance to tumor antigens
