hypersensitivity Flashcards
the first three type of hypersensitivity are mediated by
anti-bodies
the fourth type of hypersensitivity is mediated by
T- cells and macrophages
what are the 4 common sources of allergens
inhaled, injected, ingested, contacted
type 1 sensitivity is mediated by
IgE bound to its Fc receptor on mast cells
type 1 occurs
immediately after contact
type 1 can cause….if not treated
anaphylaxis
type 2 hypersensitvity is mediated by
IgG or IgM binding to specific cells or tissues ( cytotoxic)
hypersensitivity 2 causes
cell destruction
what is an example of hypersensitivity type 2 reaction
- transfusion reaction
-hemolytic anemia in borns
hypersensitivity type 3 is mediated by
immune complex which persist and are deposited in tissues and organs
type 3 results in
complement and effector-cell-mediated damage
what are introduced to the cell in type 4 hypersensitivity
haptens
type 4 causes what to be produced
Th0 which induces other T- cell helpers
what type of sensitivity is contact dermatitis
type 4
why does contact dermatitis occur
small molecules are forming a hapten-carrier-like complex n