hypersensitivity Flashcards

1
Q

the first three type of hypersensitivity are mediated by

A

anti-bodies

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2
Q

the fourth type of hypersensitivity is mediated by

A

T- cells and macrophages

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3
Q

what are the 4 common sources of allergens

A

inhaled, injected, ingested, contacted

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4
Q

type 1 sensitivity is mediated by

A

IgE bound to its Fc receptor on mast cells

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5
Q

type 1 occurs

A

immediately after contact

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6
Q

type 1 can cause….if not treated

A

anaphylaxis

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7
Q

type 2 hypersensitvity is mediated by

A

IgG or IgM binding to specific cells or tissues ( cytotoxic)

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8
Q

hypersensitivity 2 causes

A

cell destruction

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9
Q

what is an example of hypersensitivity type 2 reaction

A
  • transfusion reaction
    -hemolytic anemia in borns
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10
Q

hypersensitivity type 3 is mediated by

A

immune complex which persist and are deposited in tissues and organs

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11
Q

type 3 results in

A

complement and effector-cell-mediated damage

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12
Q

what are introduced to the cell in type 4 hypersensitivity

A

haptens

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13
Q

type 4 causes what to be produced

A

Th0 which induces other T- cell helpers

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14
Q

what type of sensitivity is contact dermatitis

A

type 4

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15
Q

why does contact dermatitis occur

A

small molecules are forming a hapten-carrier-like complex n

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16
Q

which type of hypersensitivity is fatal fastest

A

anaphylaxis