autoimmune disease Flashcards
1
Q
what is immunological tolerance
A
unresponsiveness to an antigen
2
Q
when is peripheral tolerance induced
A
mature lymphocytes self antigens and die by apoptosis or become incapable of activation
3
Q
peripheral tolerance is maintained by
A
T-cells
4
Q
what is T-cell anergy
A
exposure of mature CD4+T cells to antigen in absence of innate immunity
5
Q
low level of costimulation can lead to
A
tolerance
6
Q
high levels of co stimulators on antigen presenting cells favor
A
immune stimulation
7
Q
most genes associated with autoimmunity have strong association to
A
MHC genes
8
Q
A
