Transfusion Flashcards
What determines blood type on RBC
Antigens
how many genes are in ABO antigens
3 (A, B, C)
what gene in the ABO is non functional
O gene
which genes are co-dominant
ABO
what do A and B gene code for
Transferase enzymes
Group A sugar is
acetylgalactosamine
Group B sugar
galactose
Group A and B antibodies are
anti-A and anti-B and predominantly IgM
group O antibodies are
anti- and anti B and mainly IgG
in group O anti-a and anti-b react against
A or B cells
group O can do what Group A and B can’t do , what is it?
cross the placenta
what ABO group is the most common
Group O
what is common to have in O moms
mild hemolytic disease fetus/ newborn
what it the universal donor
Group O
Group o have antibodies
Anti- A, Anti-B and anti- A,b
Group A:
antigens
antibody
subgroups
A
Anti-B ( mainly IgM)
A1( 80%) A2(20%)
Group B
antigens
antibodies
B
anti-A
Group AB
antigens
antibodies
A and B antigens
No antibodies
what is the least common ABO group and the universal recipient/ donor plasma
Group AB
for ABO testing the front type and reverse type should be?
opposites
severe anemia is Hb
less than 7
what do you need to watch if you keep transfusion blood
iron levels will rise due to there being iron in the additives
plasma has no
viable cells
plasma has
all the coagulation factors
when do you typically use plasma
liver disease or pts with coagulopathy issues
when do you give cryoprecipitate
low fibrinogen
what are some modifications
Leukoreduction (Decrease WBC)
Irradiation( deactivation lymphocytes)
Washing ( removal of plasma protein etc)
freezing
