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AU16 Pharm 4 > Tuberculosis > Flashcards

Tuberculosis Flashcards

1
Q

TB

Type of respiratory

A

Obligate aerobe

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2
Q

TB infection/growth rate

A

chronic/slow

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3
Q

Rifampin should be substituted with

A

Rifabutin

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4
Q

Isoniazid mechanism

A

Inhibit mycolic acid synthesis

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5
Q

Isoniazid activated by

A

Catalase peroxidase

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6
Q

Pyrazinamide mechanisms

A

Disrupt membrane potential (drop pH)
Inhibit mycolic acid synthesis
Ribosomal binding protein

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7
Q

First line therapy

A

Rifampin
Isoniazid
Pyrazinamide
Ethambutol

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8
Q

Ethambutol mechanism

A

Inhibits arabinose polymerization by arabinosyl transferase

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9
Q

Capreomycin mechansim

A

Inhibits 50s 30s protein synthesis

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10
Q

Ethionamide mechanism

A

Inhibit mycolic acid synthesis

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11
Q

Cycloserine mechanism

A

Prevent Dala and Dala-Dala formation

Inhibit Dala racemase and Dala Ligase

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12
Q

Para-aminosalicylic acid mechanism

A

Folate synthesis competitive inhibitor

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AU16 Pharm 4 (10 decks)

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