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AU16 Pharm 4 > Antiviral 50 > Flashcards

Antiviral 50 Flashcards

1
Q

Importance of M2 protein

A

Allows genome release within cells (Acidic vesicle causes M2 channel to open)

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2
Q

Importance of Neuraminidase

A

Aids in release of virus from mucous and epithelial cells
Hydrolyzes neuraminic acids from proteins: cleaves Neuraminic acid from receptors, disrupting viral hemagglutinin to cell, allowing for viral release

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3
Q

Adamantanes

Spectrum

A

Influenza A

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4
Q

Ledipasvir
Treatment
Target

A

HepC

NS5A

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5
Q

Ledipasvir
Treatment
Target

A

HepC

NS5A

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6
Q

Gp120

A

Attach to CD4 T helper cells (CCR5, CCRX4)

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7
Q

GP41

A

Critical for fusion of HIV with membrane

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8
Q

Hep C targets

A

Protease:NS3-4A
RNA polymerase: NS5B
Non structural protein NS5A

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9
Q

Functions of LTR

A
  • Integration into host genome by viral integase

- Recognized by HIV tat protein and host TF to drive transcription of HIV DNA

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AU16 Pharm 4 (10 decks)

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