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AU16 Pharm 4 > Antiviral 1-34 > Flashcards

Antiviral 1-34 Flashcards

1
Q

Important receptors for HIV

A

CD4/CCR5

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2
Q

Infection process

A 
Adsorption
Penetration/uncoating
Replication, transcription, translation
Assembly
Release
Secondary infection
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3
Q

DNA virus replication

A

DSDNA makes single RNA and DSDNA

RNA. RNA integrates w/ host to make proteins. DSDNA assembles w/ proteins/enzymes to virion

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4
Q

RNA virus replication

A

Enter nuc to make cRNA, mRNA
cRNA–>goes to virion
mRNA: makes proteins/enzymes

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5
Q

Retrovirus replication

A

Reverse transcription to complimentary DNA–>move into nucleus
Replication (with host DNA)
Transcription, translation

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6
Q

Problems with Passive immunization

A

Allergy/hypersensitivity

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7
Q

Palivizumab mechanism

A

Passive immunization

Binds to viral F protein

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8
Q

Palivizumab spectrum

A

Respiratory syncytial virus (Bronchitis in children)

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9
Q 
Type 1 IFN produced by (3)
Activated by (1 for each)
A

Plasmacytoid dendritic cell precursors activated by TLR7, TLR9
Non-TLR activated by viral glycoproteins
Normal cells activated by DsRNA

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10
Q

Actions of IFN

A 
activates CD8 and T killers
Inhibits
Penetration/uncoating
Transcription/translation
Protein glycosylation
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11
Q

IFN resistance

Toxicity

A

Interferon antibodies
Viral anti IFN signaling
Flu like symptoms

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12
Q

Types of viruses
Herpes
Influenza

A

DNA

RNA

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13
Q

DNA viruses

A 
Herpes Simplex
Herpes Zoster
Hep B
CytoMegaloVirus
Small pox
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14
Q

RNA viruses

A

Hep C
Influenza
Respiratory Syncytial virus

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AU16 Pharm 4 (10 decks)

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