Antibiotics p14-22

Question 1

Penicillin binding protein

Answer 1

Transpeptidase

Question 2

MRSA

Answer 2

Methicillin resistant S. aureus

Altered PBP and low affinity for all beta lactam drugs

Question 3

Types of penicllin

Answer 3

-Natural: narrow
-Antistaphylocoocal(B lactamase resistant)(Methicillin): narrow
-Amino: broader
AntiPseudomonal: Extended

Question 4

Effect of B lactamase

Answer 4

Breaks down penicillin and increases MIC

Question 5

Penicillin uses

Answer 5

S. Pneumoniae
Meningitis, epiglotitis
Syphilis
UTI

Question 6

Penicillin resistance mechanisms

Answer 6

B-lactamases (+)(-)
Altered PBP (MRSA)
Altered porins (-)
Increased efflux

Question 7

Dependence of Penicllin

Answer 7

Time dependent

Question 8

Generations of Cephalosporins

Answer 8

Increase in (-) spectrum
Decrease in (+) spectrum

Question 9

Cef/ceph is a type of

Answer 9

cephalosporin

Question 10

Ceftriaxone

Answer 10

Not effective against pseudomonas

Crosses BBB

Question 11

Carbapenem uses

Answer 11

Pseudomonas

Acinetobacter

Question 12

Clavulanic acid

Answer 12

Beta lactamase inhibitor

Used in conjuction with beta lactams

Question 13

vancomycin mechanism

Answer 13

Binds to carboxyl terminus of Dala-Dala inhibiting peptidoglycan synthase and transpeptidation

Question 14

Vancomycin resistance

Answer 14

Altered DalaDala structures so cant bind avidly

Question 15

Vancomycin uses

Answer 15

MRSA

Severe colitis