Antibiotics p7-14

Question 1

Sulfonamides

mechanism

Answer 1

Inhibit Dihydropteroate synthase required for folic acid synthethsis

Question 2

Kernicterus

Answer 2

Sulfa drug displaces albubin bound bilirubin. Bilirubin enters BBB of newborn leading to encephalopathy

Question 3

Trimethoprim mechanism

Answer 3

Inhibit Dihydrofolate reductase required for folic acid synthesis

Question 4

Rifampin use

Answer 4

Tuberculosis

Question 5

Timethoprim use

Answer 5

MRSA

Question 6

Rifampin downside

Answer 6

Induces hepatic enzymes
HIV drugs deminished
Substitute with Rifabutin

Question 7

Quinolone mechanism

Answer 7

Inhibits DNA gyrase and DNA topoisomerase IV

Question 8

Any drug ending in floxacin is

Answer 8

fluoroquinalone

Question 9

Nitrofuran mechanism

Answer 9

Formation of oxygen free radicals

Question 10

Metronidazole use

Answer 10

Anaerobic infections

Question 11

Contraindication to nitrofuran

Answer 11

Poor renal function . Pulmonary fibrosis associated toxicity

Question 12

Resistance to inhibiting cell wall synthesis

Answer 12

Mycoplasma (no cell wall)

L forms of bacteria (no wall)

Question 13

Cycloserine

Answer 13

inhibits L-ala-D-ala and D-ala-D-ala linkage