TSM 1.11 Flashcards
1
Q
what is the Neuromuscular junction?
A
- specialised form of synapse
2
Q
what enzyme converts acetyl-CoA to acetylcholine?
A
choline acetyltransferase
3
Q
what are the stages of NMJ synaptic transmission?
A
- impulse cause increase permeability of calcium
- release of transmitter
- Ach binds to nicotinic receptors
- increase of sodium and potassium conductance
- generate end plate potential
4
Q
what does SNARE proteins do?
A
- drag and pull the vesicle so that it cause fusion between vesicles and membrane
5
Q
what does synaptobrevin do?
A
connect to vesicles and help with fine tuning
6
Q
what does syntaxin do?
A
syntaxin helps to form stable SNARE complex
7
Q
what does SNAP 25 do?
A
specificity of membrane fusion
8
Q
what is quantal release?
A
- neurotransmitter in one vesicle –> quantum
9
Q
what are subjunctional fold?
A
fold in the membrane of skeletal muscle
10
Q
what is at the top of the fold?
A
nicotinic acetylcholine receptors
11
Q
what is at the bottom of the fold?
A
voltage sensitive sodium channels
12
Q
what is within the folds?
A
acetylcholinesterase
13
Q
what enzymes breakdown acetycholine?
A
acetylcholinesterase
14
Q
what does BoTox do?
A
- made up of light and heavy chain
- heavy chain allows protein to bind to and enter neurone
- light chain cleaves vesicle docking protein
15
Q
what does curare do?
A
- competes with acetylcholine for receptor sites
