Trimethoprim

Question 1

Sourse of trimethoprim ?

Answer 1

Synthestic drug

Question 2

Chemically ?

Answer 2

Not sulphonamide . acts synergistically with some sulphonamides

Question 3

Mode of action ?

Answer 3

Acts by inhibtion of Dihydrofolate reductase with affinity for bacterial enzemes 50000 times that for humans .

Question 4

Spectrum ?

Answer 4

Is apotent broad spectrum bacteriostatic agent

Question 4

Spectrum ?

Answer 4

Is apotent broad spectrum bacteriostatic agent

Question 5

Uses ?

Answer 5

Used for UTI and for prophylaxis of UTI

Question 6

Why we give it with same sulphonamide?

Answer 6

Emergence of resistant strains is increasing so is usually used in combination with sulphonamide, to give synergistic action .

Question 7

Adverse effects ?

Answer 7

1- GIT disturbances including : anorexia , nausea and vomitting
2- hypersesitivity : ueticaria , skin rash , photesensitisty
3- Crystalluria may accur if adequate amount of water is not taken during therapy
4- haematopoeitic disturbances : acute haemolytic anaemia , agranulocytosis , aplastic anaemia