Trimethoprim Flashcards

1
Q

Sourse of trimethoprim ?

A

Synthestic drug

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2
Q

Chemically ?

A

Not sulphonamide . acts synergistically with some sulphonamides

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3
Q

Mode of action ?

A

Acts by inhibtion of Dihydrofolate reductase with affinity for bacterial enzemes 50000 times that for humans .

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4
Q

Spectrum ?

A

Is apotent broad spectrum bacteriostatic agent

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4
Q

Spectrum ?

A

Is apotent broad spectrum bacteriostatic agent

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5
Q

Uses ?

A

Used for UTI and for prophylaxis of UTI

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6
Q

Why we give it with same sulphonamide?

A

Emergence of resistant strains is increasing so is usually used in combination with sulphonamide, to give synergistic action .

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7
Q

Adverse effects ?

A

1- GIT disturbances including : anorexia , nausea and vomitting
2- hypersesitivity : ueticaria , skin rash , photesensitisty
3- Crystalluria may accur if adequate amount of water is not taken during therapy
4- haematopoeitic disturbances : acute haemolytic anaemia , agranulocytosis , aplastic anaemia

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