B Lactamse inhibitors

Question 1

What is B - lactamse inhibitors ?

Answer 1

Some agents can bind to B- lactamase enzyme and inhibit its activity

Question 2

Affect ?

Answer 2

Preventing degredation of B- lactam antibiotics which consequently leads to prolongation of T 1/2 and obtaining better / therapentic effects . B- lactamase inhibitors are given in combiation with B-lactam administered

Question 3

Best example

Answer 3

Clavulanic acid

Question 4

Clavulanic acid ?

Answer 4

Is produced by streptomyces clavuligerus , has poor antimicrobial effect so is not used separately as an antibiotic . is used in combination with B- lactams as a ( succide ) inhibitor

Question 5

Pharmacokinetics ?

Answer 5

Well absorbed orally , can be administered parentrally .Metabolism is hepatic , excretion is urinary

Question 6

Therapentic use ?

Answer 6

Used in combination with Amoxicillin ( Augmentin) for oral administration .
They leads to potentiation of the therapeutic effect of Amoxicillin.

Question 7

Dose ?

Answer 7

1 tablet (300 mg Amoxicillin+ 75mg clavulanic acid ) every 8 hours