Classification

Question 1

Classification according to chemical structure and proposed mode of action ?

Answer 1

1- agents that inhibit bacterial cell wall synthesis
2- agents acting directly on cell membrame of micro- organisim affecting permeability and leading to leakage of intracellular contents
3- agents which affect the function of 30 S or 50 S
4- agents that bind to the 30 S ribosomal subuit and leading to alteration in protein biosynthesis which eventually leads to cell death
5- agents that affect nucleic acid metabolism
6- anti metabolites
7- nucleic acid analogs

Question 2

Antibiotic act on cell wall synthesis?

Answer 2

1-penicillins
2- cephalosporins
3- agents as cycloserine ,vancomycin, bacitracin
4- imidazoles ( anti fungal agents)

Question 3

Antibiotic act on cell membrame ?

Answer 3

Polymyxins ( B -C)
Nystatin ( antifungal )
Amphotericin B

Question 4

Agents effect function of 30S or 50 ?

Answer 4

Causing a reversible inhibition of protein biosynthesis includes:- 
Chloramphenicol
Tetracycline 
Erythromycin 
Clindamycin

Question 5

Agents that bind to the 30S ?

Answer 5

Aminoglycosides

Question 6

Agents that affect nucleic acid metabolism ?

Answer 6

1- Rifampicin : which inhibits DNA dependant RNA polymerase

2- quinolones : which inhibits DNA grase

Question 7

Anti metabolites?

Answer 7

Block a specific metabolic steps that are essential for the micro - organism includes :
Trimethoprim
Sulphonamides

Question 8

Nucleic acid analogs ?

Answer 8

Act by inhibiting viral enzymes and which are essential for DNA synthesis, thus viral replication