Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Biochemistry Fall MS1 > Tricarboxylic Acid Cycle > Flashcards

Tricarboxylic Acid Cycle Flashcards

1
Q

does the TCA cycle require oxygen

A

Yes it operates aerobically

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

where does the TCA cycle occur ?

A

mitochondrion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what compounds can be converted to acetyl coA and enter the TCA cycle ?

A

pamitate, glucose, acetoacetate, ethamol and alanine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what vitamins and coenzymes are required for the TCA cylce ?

A

coenzyme A, niacin, riboflavin, thiamine, lipoic acid, and biotin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

in order to begin the TCA cycle you need to converte pyruvate to what compound /

A

acetyl coA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

how do we convert pyruvate to acetyl coA ?

A

via the pyruvate dehydrogenase complex

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what are the 5 enzymes required for the conversion of pyruvate to acetyl CoA

A

NAD, CoA, thiamine, lipoate, and FAD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

per oxidation of acetyl CoA how many ATP and NADH and FADH2 do we get

A

3 NADHm, 1 FADH and 2 CO2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what is the role of OAA

A

the role of OAA is to produce a 4 C intermediate that can combine with acetyl CoA a 2 carbon intermediate to forma 6 carbon unit

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what enzyme is required to convert acetyl CoA to Citrate ?

A

citrate synthase (uses OAA)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

oxidation and decarboxylation of isocitrate uses what enzyme ?

A

isocitrate dehydrogenase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

oxidation and decarboxylation of isocitrate converts it to

A

alpha ketoglutarate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

citrate is converted to isocitrate via

A

aconitrase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

alpha ketoacid dehydrgoenase complex requires what coenzymes

A

thimain, lipoate and FAD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

alpha ketoacid dehydrogenase converts alpha ketoglutarate to

A

succinyl CoA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what is associated with alcoholis

A

thiamine absorption (beri beri disease_

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

wet beri beri

A

edema, heart failure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

dry beri beri

A

polyneuropathy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

the conversion of succinly coA to succine uses what enzyme

A

succinate thiokinase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

the conversion of succinly CoA to succinate produces

A

GTP (substrate level phosphorlyation)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

what is convanetly attached to succinate thiokinase ?

A

FAD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

where is succinate thiokinase located

A

the inner mitochondrial membrane

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

where are all enzymes except succinate thiokinase located ?

A

mitochondrial matrix

24
Q

succinate to fumarate produces

A

1 FADH2

25
Q

malate to OAA produes

A

1 NADH

26
Q

iosicitrate to alpha ketoglutarate produces

A

1 NADH

27
Q

alpha ketoglutuarea to succinyl CoA produces

A

1 GTP

28
Q

citrate can be sent for

A

fatty acid synthesis

29
Q

alpha ketogluturate can be sent for

A

amino acid synthesis and neurotransmitters

30
Q

malate can be sent for

A

gluconeogensis

31
Q

OAA can be sent for

A

amino acid synthesis

32
Q

succinyl CoA can be sent for

A

heme synthesis

33
Q

amino acids can be used to make ________which then can help replenish

A

pyruvate, OAA

34
Q

acetyl CoA and be made from

A

carbohydrates, fatty acids, and amino acids

35
Q

what is used to help reproduce alpha ketoglutarate

A

glutamate

36
Q

what is used to produce propionyl CoA

A

valine, isoleucine, and odd chain fatty acids

37
Q

proprionyl CoA is converted to

A

succinyl CoA

38
Q

aspartate can be used to create

A

OAA

39
Q

what can be used to form fumarate

A

amino acids

40
Q

what is the enzyme that is required to replenish OAA

A

pyruvate carboxylase

41
Q

when acetyl CoA increases what is the action on pyruvate carboxylase ?

A

activates it

42
Q

what coenzme does pyruvate carboxylase require

A

biotin (vitamin B), thimain pyrophosphate, lipoate, and FAD

43
Q

what is the significance of avidin ?

A

avidin is a complex with avidin causing a biotin deficiency

44
Q

what are the activators of pyruvate dehydrogenase

A

pyruvate, CoA, NAD, calcium and ADP

45
Q

inhibitors of pyruvate dehydrogenase

A

acetyl CoA and NADH

46
Q

rate of flux through the TCA cycle depends on

A

ration of NADH to NAD and ATP to ADP

47
Q

what are the major sites of regulation through the TCA cycle ?

A

isocitrate dehydrogenase and alpha ketoglutarate dehyrogenase

48
Q

what are the inhibitors of isocitrate dehydrogenase

A

NADH

49
Q

what are teh inhibotrs of alpha ketogluturate dehydrogenase

A

NADH

50
Q

what are the activators of alpha ketoglutarate dehydrogenase

A

calcium

51
Q

what are the activators of isocitrate dehydrogenase

A

calcium and ADP

52
Q

how do we get proteins imported into the mitochondria ?

A

chaperone proteins

53
Q

what is the translocase in the outer memebrane

A

TOM complex

54
Q

what is the translocase in the inner membrane

A

TIM

55
Q

what is the chaperone in the matrix

A

HSP60

Biochemistry Fall MS1 (12 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions