Cell Signaling Flashcards
the epinephrine beta receptor causes
blood vessel dilation in the skeletal muscle
examples of intracellular receptors
thyroid hormone, coritsol, aldoslterone, vitamin D3, and retinoic acid
RAF, MEK, ERK is example of what pathway
RAS pathway
the acetylcholine receptor is an example of a
ligand gated ion channel
insulin release is what type of receptor
ligand gated ion channel (calcium gated ion channel)
when GDP is bound is the G protein active or inactive
inactive
is GDP bound to alpha or beta or gamma suunit
alpha
________stimulates adenylyl cyclase
G alpha S
_______________inhibits adenly clyase
Galpha I
G alpha q
activates phospholipase Cbeta
examples of G alpha S
glucagon, epinpenephrine
examples of G alpha I
epinephrine, many neurotransmitters, including acetyl choline, dopamine, and serotonin
examples of G alpha q
ephinephrine, acetyl choline, histamin and TSH
explain the process of signaling through cAMP and glycogen breakdown
adrenaline binds, activates GPCR, GS activates adenyl cyclase which makes cyclic AMP which then acts to activate PKA which turns on phosphorylase kinase which activates glycogen phosphorylase
acetylcholine-adenosine in cardiac muscle is an example of
G inhibitory
epinpherine signaling through cAMP gene transcritpion
activated GPCR activates adehyly cyclase which activates cAMP making active PKA, enters the nucleus through a pore and acts as a phosphorylated transcription regulator
PIP may be generated by
RTK or GPCR signaling
PIP2 creates
DAG and IP3
funcion of IP3
second messengers
PIP3 function
docking site for plechstrin homology domains
PLP and IP3 and DAG signaling causes
opening of calcium channels in endoplasmic reticulum
RAS and MAPK pathway is an example of
RTK signaling
pathway of RTK signaling
growth factor binds, RAS binds RAF and initiates map kinase pathway
RTK singaling functions in
regulation of cell growth
insulin receptor and PI13L is an example of
RTK signaling
JAK-STAT signaling is important in
regulation of immune system, cell growth, differentiation and death
STATs are
transcritpion factors and go to the nucleus
Ser/THr kinases receptors are important in
tissue differentiation and organ development
RSMAD binds COSMAD and migrates to the nucleus is an example of
ser.thr kinase receptors
three ways signals can be terminated
receptor inactivation, receptor internalization, and receptor degradation
cholera and Her2 is an example of when there is
excessive response in cell signalng
type 1 diabetes and insulin resistance in type 2 diabetes is an example of
failure to respond
