Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Block 3 Pharm > Treatment of fungal infections > Flashcards

Treatment of fungal infections Flashcards

1
Q 
Vaginal Candida (single oral dose)
 -	Also for Candida in urinary tract and oropharynx
A

Fluconazole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

creams/suppositories for vaginal candidiasis

- Toxicity of topical preps.: burning, itching, irritation

A

Miconazole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Mechanism for Miconazole

A

inhibit sterol 14α-sterol demethylase

fungistatic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Miconazole is used for:

A

Oral or vaginal candidiasis
not nails available topically
mech like fluconazole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Toxicity of Miconazole

A

allergic/irritation reactions

- Oral form toxicity: may cause abnormal liver function tests (15%),

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Use of Itraconazole

A
  • Oropharyngeal and esophageal candidiasis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Almost exclusively for Candida of skin, mucous membranes, G.I. tract, vaginal infections
- Mechanism similar to amphotericin B

A

Nystatin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Mech of Nystatin

A

Nystatin (lika amphoB)

binds ergosterol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Side effects of Nystatin

A

tastses NASTY and GI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q 
Amphotericin B
(does it work for dermatophytes?)
A

topical formulation for cutaneous or mucosal
Candida -
not effective against dermatophytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

For fungal eye infections, e.g. conjunctivitis, keratitis, blepharitis
• especially those caused by Fusarium, Cephalosporium, Aspergillus

A

Natamycin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Natamycin must be used in conjuction with

A

appropriate surgical measures

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Toxicity caused by Natamycin

A

conjunctival chemosis and hyperemia, allergic in nature

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Mech of Natamycin

A

lipophilic and binds ergosterol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

type of Dermpatophytic infections:

A

(Trichophyton, Epidermophyton, Microsporum)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Terbinafine (Lamisil):

A

topical, for dermatophytes

17
Q

Use: this lacquer is the only topical Rx for fungal nail infections

A

Ciclopirox

(ciclops only has nails… everyint e

18
Q

Ciclopirox mechanism

A

possibly inhibits metal-dependent enZ by chelating metal ions

19
Q

Tolnaftate

A

-tx dermapthophytes (not Candida); no significant absorption,
few toxic reactions; thought to inhibit fungal ergosterol synthesis

20
Q

Mech of Tolnaftate

A

inhibit fungal ergosterol synthesis

21
Q

Terbinafine

A

12 week therapy for nail infections~ shorter then other dermatophyte infections
superior to grisefulvin for nail infections

22
Q

Mech of Terbinafine

squaline for 12 weeks and 2x6 = 12

A

inhibits fungal squalene epoxidase; non-competitively; lotsa squalene damages fungal cell membranes; fungicidal

23
Q

blocks fungal squalene epoxidase

accumulation of squaline damages cell membrane~~ fungicidal

A

Terbinafine

24
Q

Terbinafine;
administration:
Metabolism/excretion:

A

oral, well absorbed; remains in skin 12 weeks after therapy stopped
metabolites excreted in urine

25
Q

Terbinafine toxicity

A

inhibits CYP2D6

diarheaa

26
Q

For stuborn infections of skin, hair, nails, that are beyond the scope of topical
therapy

A

Griseofulvin

27
Q

Recommended therapy for children, esp. for tinea capitis

A

Griseofulvin

28
Q

Tx length with Griseofulvin

A

Long-term treatment (6–12 months) esp. for nail infections; clinical relapse will
occur if long-term treatment not completed

29
Q

Mech of Griseofulvin

micortubles~ metaphase

A

slowly deposited into skin, hair, nails; interferes with microtubule
function/mitotic spindle/mitosis; arrests fungi in metaphase of mitosis.

30
Q

only for Epidermophyton, Microsporum, Trichophyton (dermatophytic) infections of skin, hair, nails; not justified for skin infections which respond to topical agents

A

Griseofulvin

microtubles, metaphase

31
Q

Is Griseofluvin Fungistatic or fungicidal?

A

Both Fungistatic or fungicidal, dependent on fungal metabolic rate

32
Q

Administration of Griseofulvin

A

Oral with high fat foods

use wth others when tx tenia pedis

33
Q

Toxicities of Griseofulvin

A

Dont use if porphyria and advanced liver disease;
monitoring of hepatic, renal, and hematopoietic systems recommended - Increased metabolism of other drugs (e.g. oral contraceptives, warfarin,
others)
- caution: penicillin allergies

34
Q

Contraindicated in those with porphyria and advanced liver disease; periodic
monitoring of hepatic, renal, and hematopoietic systems recommended - Increased metabolism of other drugs (e.g. oral contraceptives, warfarin,
others)
- caution: penicillin allergies

A

Griseofulvin

35
Q

3-month therapy for toenail infections

A

Itraconazole

36
Q

Itraconazole

A

Discontinue if signs of liver dysfunction appear Inhibits metabolism of many drugs,
Nausea, vomiting, rash, diarrhea, headache, edema

Block 3 Pharm (19 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions