Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Block 3 Pharm > Antipyschotics/antimanias > Flashcards

Antipyschotics/antimanias Flashcards

1
Q

Alliphatic side chain and D2 antagonist

A

Chlorpromazine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Chlorpromazine
potency:
sedative?
effects

A

Low-medium potency,
sedative,
large anti-cholinergic.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Acute psychotic episodes, chronic schizophrenia, tourette’s, antiemisis.
Typicals only do Positive symptoms

A

Chlorpromazine
Thioridazine
Fluphenazine
Haloperidol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Low potency, sedative, less EPS, anticholinergic.

Piperidine side chain

A

thioridazine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

thioridazine
potency
sedative?
effects

A

low potency
sedative
less ExtraPyramidalS and anticholinergic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

*Early Rx (dystonia, parkinsonism, akathisia),
Late Rx (Tardive dysnkinesia).
Neuroleptic Malignant Syndrome.
Sedation, neuroendocrine effects, orthostatic hypotension, weight gain - *diabetes related events.

A

Extrapyramidal symptoms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

High potency, less sedative, less anticholinergic, more EPS. Piperazine side chain

A

Fluphenazine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Fluphazine
potency:
sedation?
extras

A

High potency
less sedation/less anticholinergic
more extrapyramidials

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

typical with piperazine side chain

A

fluphenazine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Initial control of manic episode

A

Haloperidol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Butyrophenone Derivative

A

Haloperidol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

High potency, less sedation, more EPS

A

Haloperidol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Haloperidol (typical) use

A

initial control of manic episode

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Atypicals

for both + and -

A 
Clozapine
Olanzapine
Risperidone
Quetiapine
Arpiprazole
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What does Clozapine act on?

A

D4 (D2 like) and 5-HT2 antagonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Side effect of Clozapine

A

Seizures, agranulocytosis.
Really gonna close line you with this agranulocytosis
*Atypicals have less EPS, and more diabetes events.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Can cause agranulocytosis and seizures and make you fat

A

Clozapine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Less seizures than Clozapine, and no agranulocytosis, but worse weight gain and diabetes related adverse events.

A

Olanzapine

“O” is round… just like your waist on this drug, but at least you wont die from agranulocytosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

D1, D2, and 5-HT2 antagonist

A

Olanzapine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

atyipical good for manic episodes

A

olanzapine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Olanzipine has more or less EPS

A

LESS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Risperidone (atypical) acts on

A

D2 and 5-HT2 antagonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Less seizure and less antimuscarinic than Clozapine.

A

Risperidone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Paliperidone is its active metabolite

A

Risperidone

25
Q

MEch of Quetiapine

A

D2 and 5-HT2 antagonist

26
Q

Uses of Quetiapine besides schizo

A

augmentation in depression, manic episodes

27
Q

Partial D2 AGONIST, and 5-HT2 antagonist

A

Aripiprazole

28
Q

uses of aripiprazole

A

augmentation in depression and manic episodes

29
Q

what two atypicals can help with depression and manic episodes

A

risperidone and aripiprazole

30
Q

Interferes with Phosphoinositide cycle -> less DAG/IP3

A

Lithium

31
Q

Use of Lithium

A

Manic episodes and prophylaxis of bipolar depression and mania, cluster heacaches

32
Q

Manic episodes and prophylaxis of bipolar depression and mania, cluster heacaches

A

Lithium

33
Q

What’s worrisome about Lithium?

A

Narrow therapeutic window. Fatigue and muscle weakness, tremor, GI symptoms, goiter, slurred speech, ataxia. Serious toxicity - impaired conciousness, rigidity and hyperreflexia, coma.

34
Q

What type of meds should we be careful of when prescribing Lithium?

A

anything that increases Na+ excreation

35
Q

Use of Valproic acid

A

sedation and bipolar

36
Q

5-HT1 partial agonist, dopamine agonist for anti-anxiety

A

Buspirone

37
Q

Anxiety, sleep disorders, seizures , Panic disorders, IV sedation and anesthesia

A

Alprazolam

38
Q

Alprazolam is a

A

benzo agonist on GABA (enhances it)

39
Q

BDZ Withdrawal:

A

anxiety, insomnia, irritability, headache, hyperacusis, hallucinations, seizures (thus, wean off or switch to long-acting or Buspirone)

40
Q

Contraindications of Alprazolam

A

Other CNS depressants, hepatic metabolized drugs (cimetidine)

41
Q

Benzo for Muscle relaxant, Alcohol withdrawal

A

Diazepam

42
Q

How does Diazepam work

A

Benzo GABA agonist

43
Q

Fast onset (lipophilic), rapid into brain, rapid redistribution, active metabolites (Desmethyldiazepam)

A

Diazepam

44
Q

Slow onset, long duration of action, no active metabolites, Benzo for sleep

A

Lorazepam

45
Q

Lorazepam uses

A

anxiety and sleep disorder but is especially hypnotic!

46
Q

anxiety and sleep disorder but is especially hypnotic!

A

Lorazepam

47
Q

Cause increase in sleep stages 1-2, and decreased 3-4 and REM and rebound insomnia on withdrawl

A

Lorazepam

48
Q

Lorazepam mech

A

benzo GABA agonist

49
Q

Rapid onset, long duration and is a more hypnotic benzo

A

Flurazepam

50
Q

Flurazepam mech

A

benzo GABA agonist

Hypnotic, weak anxiety

51
Q

Difference between Flurazepam and Lorazepam

A

Flurazepam is weakly anxiolytic and is longer acting with rapid induction…
both are hypnotic

52
Q

Side effects of Zolpidem

A

Daytime sedation, ataxia, rebound insomnia, tolerance/dependence, occasional idiosyncratic stimulation

53
Q

Mech of Zolpidem

A

NON-BDZ agonist on GABA

hypnotic

54
Q

Flumazenil mech

A

BDZ antagonist ~~~~

Antagonize Zolpidem.

55
Q

BDZ antagonist ~~~~

Antagonize Zolpidem.

A

Flumazenil

56
Q

Pentobarbital (barbituate) side effects

A

Acute poisoning: stupor, coma, resp. depression. Withdrawal can cause life-threatening seizures.

57
Q

Pentobarbital mech

A

Barbiturate site on GABA

58
Q

Pugent, caustic taste. Metabolized to trichloroethanol (active)

A

chloral hydrate

Block 3 Pharm (19 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions