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Block 3 Pharm > Opiod Drug I > Flashcards

Opiod Drug I Flashcards

1
Q

Morphine works on what receptor

A

Mu agonist

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2
Q

4-5 hrs analgesia for mod to severe pain

A

morphine

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3
Q

Side effects of all Mu agonists

A

Constipation, euphoria, sedation, resp. depression, nausea, decreased LH release, increased ADH secretion (mu) or decreased (kappa), pupillary constriction

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4
Q

Has a large 1st pass in oral dose

A

morphine

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5
Q

Constipation, euphoria, sedation, resp. depression, nausea, decreased LH release, increased ADH secretion (mu) or decreased (kappa), pupillary constriction

A

side effects of all mu agonists

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6
Q

Can cause gall stones!

A

Fentanyl

i would faint if i had gall stones!

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7
Q

100x as potent as Morphine, short duration (1-1.5 hrs)

A

Fentanyl

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8
Q

Fentanyl uses:

A

100x potent as morphine and short duration

given as patch or IM

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9
Q

Used for moderate to severe pain. Conscious sedation (short-duration) as a patch or IM

A

Fentanyl

“its Fen-tastic!!! its 100x more potent AND i’m conscious”

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10
Q

Fentanyl works on which R

A

mu agonist

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11
Q

MOderate to severe pain but longer acting then morphine

A

methedone

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12
Q

because of it’s longer duration… some concern with OD fatality and abuse

A

Methadone

methadone… you could be DONE :(

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13
Q

Forms toxic metabolite normeperidine

A

Meperidine

…NO..meperidine~ normeperidine = toxic

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14
Q

Moderate to severe pain.
Conscious sedation
(short-duration)

A

Meperidine (opioid)

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15
Q

Meperidine:
pain
type of sedation
duration

A

moderate to sevre
short duration
consious sedation

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16
Q

Contraindicated if you use Meperidine (opioid)

A

MAOIs

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17
Q

Prodrug, highly lipophilic and gets to brain quickly

A

Heroin (opioid)

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18
Q

weak mu agonist

A

Codeine

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19
Q

used for mild pain and is antitussive

A

codeine

—codeine for cough but a bitchy pain helper

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20
Q

uses of codeine

A

mostly antitussive, some pain relief and given in mixutre with acetominophen or aspirin

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21
Q

Pro-drug - some is metabolized to morphine. Antitussive.

A

Codeine

22
Q

more efficacious then codeine and for moderate to severe pain

A

oxycodone

23
Q

Oxycodone is a

A

mu agonist opioid

24
Q

Sustained release oral (major abuse)

A

oxycodone

25
Q

Codeine like efficacy for mild to moderate pain

A

Hydrocodone `aka Vicodin

26
Q

opiod that is 2-3x as potent as Morphine

A

hydromorphone~~~ Mu agonist

27
Q

Nalbuphine receptor actitivity:

A

mu antagonist,

kappa agonist

28
Q

Mu antagonist, kappa agonist

A

Nalbuphine

29
Q

Nalbuphine’s efficacy profile

A

Similar to Morphine, but little euphoria and low abuse

30
Q

Who would get nalbuphine?

A

used to precipitate opioid withdrawl

31
Q

used to precipitate opioid withdrawl

A

nalbuphine or Buprenorphine

32
Q

Delivery of Nalbuphine

A

IM only

33
Q

Buprenorphine receptor activity

A

partial mu agonist

34
Q

Given oral or as a patch to opioid dependents along with naloxone for opioid dependence

A

Buprenorphine

35
Q

Naloxone (opioid antagonist) on what receptors

A

Mu antagonist, less so for kappa and delta

36
Q

Only works when injected/crushed; not orally.

Thus, prevents abuse when given with opioid (buprenorphine). 1-2 hr duration.

A

Naloxone

37
Q

How do we deliver naloxone

A

crushed/injected with opiod (buprenorphine)

38
Q

Naloxone is most active:

A

given parenterally then orally

39
Q

you mix this with buprenorphine to help with opiod withdrawl

A

Naloxone

40
Q

Inhibits reward of opiates and alcohol. 24+ hr duration

A

Naltrexone

41
Q

Naltrexone is a (receptro)

A

Mu antagonist

na—-TREX–one) trex aren’t something we want… antagonist (vs naloxone are agonist

42
Q

What does Naltrexone do

A

inhibits the reward system of opioites

43
Q

What drug tx alcohol and opioate abuse

A

naltrexone

44
Q

Dextramethorphan works on what R

A

NMDA antagonist… antitussive

-dextramethorphaNNNNN…..NMDA

45
Q

NMDA antagonist that is antitussive

A

Dextramethorphan (opioid related)

46
Q

Weak Mu agonist, blocks NET and SERT

A

Tramadol (opioid related)

47
Q

Tramadol R activity

A

weak Mu agonist and blocks NET and SERT

transvestite because does both Mu agonist then NET and SERT

48
Q

Tramadol is used for

A

mild to moderate pain (oral and sustained release)

49
Q

Combination of Buprenorphine and Naloxone to tx opioid dependence

A

Suboxone

50
Q

Cough suppresants

A

Codeine, hydrocodone and dextromethorphan

51
Q

Codeine and heroin are activated by

A

metabolism

Block 3 Pharm (19 decks)

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