Opiod Drug I

Question 1

Morphine works on what receptor

Answer 1

Mu agonist

Question 2

4-5 hrs analgesia for mod to severe pain

Answer 2

morphine

Question 3

Side effects of all Mu agonists

Answer 3

Constipation, euphoria, sedation, resp. depression, nausea, decreased LH release, increased ADH secretion (mu) or decreased (kappa), pupillary constriction

Question 4

Has a large 1st pass in oral dose

Answer 4

morphine

Question 5

Constipation, euphoria, sedation, resp. depression, nausea, decreased LH release, increased ADH secretion (mu) or decreased (kappa), pupillary constriction

Answer 5

side effects of all mu agonists

Question 6

Can cause gall stones!

Answer 6

Fentanyl

i would faint if i had gall stones!

Question 7

100x as potent as Morphine, short duration (1-1.5 hrs)

Answer 7

Fentanyl

Question 8

Fentanyl uses:

Answer 8

100x potent as morphine and short duration

given as patch or IM

Question 9

Used for moderate to severe pain. Conscious sedation (short-duration) as a patch or IM

Answer 9

Fentanyl

“its Fen-tastic!!! its 100x more potent AND i’m conscious”

Question 10

Fentanyl works on which R

Answer 10

mu agonist

Question 11

MOderate to severe pain but longer acting then morphine

Answer 11

methedone

Question 12

because of it’s longer duration… some concern with OD fatality and abuse

Answer 12

Methadone

methadone… you could be DONE :(

Question 13

Forms toxic metabolite normeperidine

Answer 13

Meperidine

…NO..meperidine~ normeperidine = toxic

Question 14

Moderate to severe pain.
Conscious sedation
(short-duration)

Answer 14

Meperidine (opioid)

Question 15

Meperidine:
pain
type of sedation
duration

Answer 15

moderate to sevre
short duration
consious sedation

Question 16

Contraindicated if you use Meperidine (opioid)

Answer 16

MAOIs

Question 17

Prodrug, highly lipophilic and gets to brain quickly

Answer 17

Heroin (opioid)

Question 18

weak mu agonist

Answer 18

Codeine

Question 19

used for mild pain and is antitussive

Answer 19

codeine

—codeine for cough but a bitchy pain helper

Question 20

uses of codeine

Answer 20

mostly antitussive, some pain relief and given in mixutre with acetominophen or aspirin

Question 21

Pro-drug - some is metabolized to morphine. Antitussive.

Answer 21

Codeine

Question 22

more efficacious then codeine and for moderate to severe pain

Answer 22

oxycodone

Question 23

Oxycodone is a

Answer 23

mu agonist opioid

Question 24

Sustained release oral (major abuse)

Answer 24

oxycodone

Question 25

Codeine like efficacy for mild to moderate pain

Answer 25

Hydrocodone `aka Vicodin

Question 26

opiod that is 2-3x as potent as Morphine

Answer 26

hydromorphone~~~ Mu agonist

Question 27

Nalbuphine receptor actitivity:

Answer 27

mu antagonist, | kappa agonist

Question 28

Mu antagonist, kappa agonist

Answer 28

Nalbuphine

Question 29

Nalbuphine's efficacy profile

Answer 29

Similar to Morphine, but little euphoria and low abuse

Question 30

Who would get nalbuphine?

Answer 30

used to precipitate opioid withdrawl

Question 31

used to precipitate opioid withdrawl

Answer 31

nalbuphine or Buprenorphine

Question 32

Delivery of Nalbuphine

Answer 32

IM only

Question 33

Buprenorphine receptor activity

Answer 33

partial mu agonist

Question 34

Given oral or as a patch to opioid dependents along with naloxone for opioid dependence

Answer 34

Buprenorphine

Question 35

Naloxone (opioid antagonist) on what receptors

Answer 35

Mu antagonist, less so for kappa and delta

Question 36

Only works when injected/crushed; not orally. | Thus, prevents abuse when given with opioid (buprenorphine). 1-2 hr duration.

Answer 36

Naloxone

Question 37

How do we deliver naloxone

Answer 37

crushed/injected with opiod (buprenorphine)

Question 38

Naloxone is most active:

Answer 38

given parenterally then orally

Question 39

you mix this with buprenorphine to help with opiod withdrawl

Answer 39

Naloxone

Question 40

Inhibits reward of opiates and alcohol. 24+ hr duration

Answer 40

Naltrexone

Question 41

Naltrexone is a (receptro)

Answer 41

Mu antagonist | na----TREX--one) trex aren't something we want... antagonist (vs naloxone are agonist

Question 42

What does Naltrexone do

Answer 42

inhibits the reward system of opioites

Question 43

What drug tx alcohol and opioate abuse

Answer 43

naltrexone

Question 44

Dextramethorphan works on what R

Answer 44

NMDA antagonist... antitussive | -dextramethorphaNNNNN.....NMDA

Question 45

NMDA antagonist that is antitussive

Answer 45

Dextramethorphan (opioid related)

Question 46

Weak Mu agonist, blocks NET and SERT

Answer 46

Tramadol (opioid related)

Question 47

Tramadol R activity

Answer 47

weak Mu agonist and blocks NET and SERT | transvestite because does both Mu agonist then NET and SERT

Question 48

Tramadol is used for

Answer 48

mild to moderate pain (oral and sustained release)

Question 49

Combination of Buprenorphine and Naloxone to tx opioid dependence

Answer 49

Suboxone

Question 50

Cough suppresants

Answer 50

Codeine, hydrocodone and dextromethorphan

Question 51

Codeine and heroin are activated by

Answer 51

metabolism