Anti-depressants

Question 1

MEch of Amitriptyline

Answer 1

Increase 5-HT and NE in synpase

TCA

Question 2

Major depressive disorder, chronic pain. Prevent Migraines

Answer 2

Amitriptyline

Question 3

Side effects of amitriptyline or clomipramine (the TCAs)

Answer 3

Decreases REM/increases stage 4 sleep, anticholinergic, sedation, *cardiac abnormalities. Acute overdose -> hyperpyrexia, hyper- or hypotension, seizures, coma, cardiac conduction defects

Question 4

Decreases REM/increases stage 4 sleep, anticholinergic, sedation, *cardiac abnormalities

Answer 4

amitriptyline/clomipramine

TCAs

Question 5

Drug interactions of Amitriptyline

Answer 5

Drug interactions: Guanethidine, blocks its uptake. Sympathomimetic drugs. Effects many drugs absorption/metabolism (via slowed gastric times).

Question 6

Amitriptyline’s half life and its danger

same for Clomipramine

Answer 6

8-100 hours so can have OD

Question 7

Clomipramine mech

same as Amitriptyline

Answer 7

Increase 5-HT and NE in synpase

TCA

Question 8

Major depressive disorder, OCD (with SSRIs)

Answer 8

Clomipramine

Question 9

Clomipramine uses

Answer 9

OCD adn MDD

Question 10

Two SSRIs

Answer 10

Fluoxetine

Sertraline

Question 11

Side effects of SSRIs

Answer 11

sexual dysnfuntion
sleep distrubance
Possible increased risk of suicide.

Question 12

When are you at risk of seratonin syndrome?

Answer 12

Serotonin syndrome if SSRIS given with MAOIs.

*Less chance of SSRI withdrawal syndrome (long-acting, 7-day half-life)

Question 13

Don’t use ____ if on SSRIs

Answer 13

MAOIs

Question 14

Major depression, affective disorders, OCD, panic disorder, social phobia, PTSD, GAD, PMS

Answer 14

SSRIs like Sertraline or Fluoxetine

Question 15

which ssri is better for PMS

Answer 15

fluoxetine

Question 16

” *Greater chance of SSRI withdrawal syndrome (short-acting)

Answer 16

Sertraline

Question 17

SSRI: Increase 5-HT in synapse. Long acting

Answer 17

Fluoxetine

Question 18

SSRI: Increase 5-HT in synapse. short acting

Answer 18

Sertraline

Question 19

Mech of Bupropion

Answer 19

weakly blocks NET and DAT to increase DA and NE

Question 20

weakly blocks NET and DAT to increase NA and DA

Answer 20

Bupropion

Question 21

Depression, nicotine withdrawal, seasonal affective disorder

Answer 21

Bupropion

Question 22

Uses of Bupropion

Answer 22

Depression, nicotine withdrawal, seasonal affective disorder

Question 23

Depression, to increase appetite in AIDS patients

Answer 23

Mirtazapine

Question 24

Mech of Mirtazapine

Answer 24

α2 autoreceptor antagonist to Increased 5-HT and NE in synpase

Question 25

α2 autoreceptor antagonist to Increased 5-HT and NE in synpase

Answer 25

Mertazapine

Question 26

Duloxetine is a

Answer 26

SNRI to block 5HT and NE reuptake

Question 27

Depression. Also, neuropathic pain syndromes, fibromyalgia, back pain, osteoarthritis pain.

Answer 27

Duloxetine

Question 28

Uses of Duloxetine

Answer 28

Depression. Also, neuropathic pain syndromes, fibromyalgia, back pain, osteoarthritis pain.

Question 29

Duloxetine is contraindicated in pts with

Answer 29

liver disease

Question 30

irreversible MAOI that Increasesd 5-HT, NE, and DA in synpase

Answer 30

Phenelzine

Question 31

Use of Phenelzine

Answer 31

narcolepsy, affective disorders, depression

Question 32

Acute toxicity: agitation, hallucinations, hyperpyrexia, convulsions, changes in BP. Tyramine (fermented foods) -> HTN crisis (causes NE release).

Answer 32

Phenelzine

Question 33

Dont eat _____ if on phenelzine

Answer 33

tyramine (fermented foods)

Question 34

MAO is found in

Answer 34

mitochondria of neurons, liver, lungs, and other organs