Generals on Opiods Flashcards
Endogenous Opioid. Precursor: POMC (as is ACTH). Found in hypothalamus, nucleus tractus solitarius, and ant. pituitary. (Runner’s high).
Acuts on mu, delta
B endorphin
B endorphin is endogenous opoid with precursor
POMC
to the MD
B endorphin acts on which receptors
mu and delta
BMD) from the POMC (it’s precursor
B endorphins are found in:
Found in hypothalamus, nucleus tractus solitarius, and ant. pituitary
Endogenous Opioid Dynorphin precursor
Prodynorphin.
Co-localizes with ADH in magnocellular cells of hypothalamus and post. pituitary.
Dynorphin
aDh—Dynorphin
Dynorphin colocalizes with :
ADH in magnocells
Dynorphin binds to
kappa
Endogenous Opioid Precursor of Enkephalin
Prokephalin.
Where is Enkephalin distributed?
Widely distrubuted in interneurons.
delta
Somatic pain. Sharp, localized pain. Terminate in lamina 1 and use glutamate.
A-Delta fibers
Visceral or neuropathic pain. Dull, diffuse, aching or burning pain. Terminate in lamina 2 and use glutamate AND substance P.
C delta fibers
Descending pain path Originate in _______
periaqueductal gray.
Descentind pain path Descend in
dorsolateral funiculus.
Point of descending pain path
Release NE, 5-HT, and Enkephalin to inhibit the ascending pathways