Ameobos and Protozoals

Question 1

Amebic dysentary:
Causative agent: Entamoeba histolytica
2. Drugs effective against trophozoites but most are not active against

Answer 1

cysts

Question 2

Eliminates orginisms in bowel, wall, liver

for sympotmatic infections

Answer 2

Tissue Amebicides

Question 3

Tissue amebicides

Answer 3

metronidazole

Question 4

Luminal amebicides

Answer 4

Iodoquiol and paramomycin sulfate

Question 5

Metronidazole

Me vagnia (trichonomas vaginalis) has a History (E. histolytica) of infectious gardens (Giardia)

Answer 5

tissue amebicide for mild to severe symptomatic infections
E. histolytica
Giardia lamblia
trichomona vaginalis

Question 6

tissue amebicide for mild to severe symptomatic infections of
E. histolytica
Giardia lamblia
tricomona vaginalis

Answer 6

Metronidazole

Question 7

effective for trophozoites in bowel lumen; luminal amebicide

Answer 7

Iodoquinol

Question 8

in combination with metronidazole for mild to severe infections of E. histolytica;

Answer 8

Iodoquinol

Question 9

Iodoquinol use

Answer 9

with metronidazole for E.histolytica

Question 10

Diarrhea and GI

• contraindicated for those hypersensitive to iodine-containing preparations

Answer 10

Iodoquinol

Question 11

Iodoquinol side effects

Answer 11

diarrhea and GI

Don’t use if ou have hypersentiivity to iodine

Question 12

Paromomycin Sulfate mech

luminal amebicide

Answer 12

aminoglycoside-like, inhibiting protein synthesis

•

Question 13

Paromomycin Sulfate side effects

Answer 13

diarrhea, nausea, vomiting, epigastric pain

Question 14

Drug for trichonoma vaginals and giardia lamblia

Answer 14

Metronidazole

Question 15

nhibits pyruvate:

ferredoxin oxidoreductase which is required for anaerobic energy metabolism

Answer 15

Nitazoxanide

NitaxOXAnide for ferredOXIN adn OXIDOreductase)

Question 16

Nitazoxanide mech

NitaxOXAnide for ferredOXIN adn OXIDOreductase)

Answer 16

nhibits pyruvate:ferredoxin oxidoreductase which is required for anaerobic energy metabolism

Question 17

uses of Nitazoxanide

Answer 17

Giardia lamblia and Crptosporium parvum

Question 18

Atovaquone used for

Answer 18

alternate prophylaxis or treatment for mild/moderate Pneumocystis jiroveci (carinii) in AIDS patients intolerant of TMP/SMX; may be -cidal for Pneumocystis
• atovaquone + rifabutin have synergistic activity against Toxoplasma gondii

Question 19

used for penumocysitis jirveci in aids or toxoplasma gondii

Answer 19

atovaquone

Question 20

act primarily in bowel lumen

~ asymtomatic or symptomatic infecions

Answer 20

Luminal amebicide