Stimulants

Question 1

Caffine low dose

Answer 1

Low dose: [Post-synaptic: inhibits IPSPs. Pre-synaptic: inhibit the inhbition of glutamate.]

Question 2

Caffeine High dose

Answer 2

High dose: [inhibit PDE3 -> bronchodilation].

Question 3

Caffeine very high dose

Answer 3

Very high dose: [induce Ca release from ER]

Question 4

Caffeine works on what R

Answer 4

Adeonsine receptor antagonist

Question 5

Caffeine adverse effects

Answer 5

Tolerance, physical dependence, withdrawal. High dose: tachycardia.

Question 6

Pre-synpatic: inhibit glutamate release

Answer 6

adenosine

Question 7

Adenosine effect on its receptor Post synaptic

Answer 7

casuses IPSPs

Question 8

Adenosine presynaptic

Answer 8

inhibit glutamate release

Question 9

Weak base; extract B from BH+ in an alkaline solution -> crack

Answer 9

Cocaine

Question 10

Tolerance, physical dependence, withdrawal. Damage to dopaminergirc neurons. Overdose: seizures, CV effects. On fetus: pre-mature, learning/emotional problems, attachment disorder

Answer 10

Cocaine toxicity

Question 11

Cocaine toxicity

Answer 11

tolernance and physical dependence… see withdrawl and damages DA neurons

Question 12

Cocaine OD

Answer 12

seizures, CV effects.

Question 13

Cocaine effect on fetus

Answer 13

pre-mature, learning/emotional problems, attachment disorder

Question 14

Mostly illicit. Local anesthetic in upper resp. surgery (nose), as its both local anesthetic and vasoconstrictor

Answer 14

Cocaine

Question 15

Reinforcing/euphora effects from Dopamine in mesolimbic. Local anesthetic, vasoconstrictor. NE -> tachycardia

Answer 15

Cocaine

Question 16

Why is cocaine addictin

Answer 16

reinforcind and euprora effects from DA in the mesolimbic area

Question 17

Inhibits NET, DAT, SERT

Answer 17

Cocaine

Question 18

What does cocaine do to result in stimulting effects

Answer 18

Inhibits NET, DAT, SERT

Question 19

Inhibits NET, DAT, SERT. Release NE, 5-HT, DA. Partial agonist of alpha. MAOI

Answer 19

Amphetamine

Question 20

What reuptakes does amphetamine inhibit?

What does it release?

Answer 20

NET, DAT, SERT

releases NE, 5HT and DA

Question 21

Amphetamine is a partial agonist of:

Answer 21

alpha MAOI

Question 22

What are the effects of amphetamine that would make someone want ot take them

Answer 22

More NE effects than cocaine. Arousal, enhance athletic and intellectual performance.

Question 23

We prescribe amphetamines for

Answer 23

Narcolepsy or ADHD

Question 24

Which has longer 1/2 life, cocaine or amphetamines

Answer 24

amphetamines

Question 25

What affects do we see for ADHD when giving amphetamines

Answer 25

decrease app, insomnai, abdominal pain, high body temp

Question 26

What we see amphetamines at high dose we see

Answer 26

restless, dizzy and pychosis (DA) and tremor

Question 27

Not-technically an Amphetamine, but structurally and mechanistically very similar

Answer 27

Methylphenidate

Question 28

Methamphetamine has same mechanism as amphetamines but higher abuse potential because

Answer 28

enters the brain better

Question 29

High dose: [restless, dizzy, tremor, psychosis (DA), neurotoxicity, meth mouth (decay, dry, grinding), abuse

Answer 29

see with methamphetamines, amphetamines

Question 30

MEch of Methamphetamines

Answer 30

Inhibits NET, DAT, SERT. Release NE, 5-HT, DA. Partial agonist of alpha. MAOI

Question 31

Nicotinic cholinergic agonist

Answer 31

Nicotine

Question 32

Nicotine effects on CNS

Answer 32

CNS stimulant -neuronal excitation/dopamine in nucleus acumbens.

Question 33

Nicotine effects on SNS PNS

Answer 33

Sympathetic: release NE from adrenal. Parasympathetic: GI stimulation

Question 34

1st cigarrette (nicotine)

Answer 34

Nausea, tolerance (rapid/tachyphylaxis -> first cig of day is best).

Question 35

Withdrawl from nicotine

Answer 35

Withdrawal: irritability, hostility, impatience, anxiety, depression, difficulty concentrating, increased appetite/weight gain

Question 36

Bupropion use

Answer 36

Nictoine withdrawal (mostly the depression)

Question 37

Nictoine withdrawal (mostly the depression)

Answer 37

Bupropion

Question 38

Inhibits NET, DAT for nicotine withdrawl

Answer 38

Bupropion

Question 39

Buproprion Inhibits

Answer 39

NET, DAT

Question 40

Side effects of Buproprion

Answer 40

xerostomia, insomnia

Question 41

More efficacious than placebo and bupropion at 12 and 24 wks

Answer 41

Varenicline

Question 42

Partial nicotinic agonist

Answer 42

Varenicline

Question 43

Varenicline is used for

Answer 43

nictotine withdrawl

Question 44

Reduce nicotine cravings; also blocks nicotine's effects if person smoked

Answer 44

Varenicline

Question 45

Side effects of Varenicline

Answer 45

Nausea, insomnia, headaches, constipation. Increased suicidal thoughts and depression