Treatment algorhtytms (including NPC) Flashcards

1
Q

Peptic Ulceration with H.Pylori (PPI)

A
esomeprazole 
20 mg 
PO 
bd
7/7
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2
Q

Peptic Ulceration with H.Pylori (Abx)

A
Amoxicillin 
1 g 
PO 
BD
7/7
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3
Q

Peptic Ulceration with H.Pylori (Abx 2)

A
Clarithromycin
500mg
PO
BD
7/7
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4
Q

Peptic Ulceration with H.Pylori (penecillin allergy)

A
Metronidazole 
400 mg
PO
BD
7/7
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5
Q

Oral iron supplementation

A

Elemental iron 100 to 210 mg
PO
OD

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6
Q

STEMI: high risk of mortality or recurrent cardiovascular event (STAT) Antiplatelet

A

Aspirin 300 mg PO then 100-150mg OD

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7
Q

NSTEACS: high risk of mortality or recurrent CS event (STAT) Antiplatelet

A

Aspirin 300 mg PO the 100-150 mg OD

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8
Q

STEMI: high risk of mortality or recurrent cardiovascular event (STAT) P2Y12 inhibitor

A

PCI: clopidogrel 600 mg then 75 mg OD
Fibrinolysis: clopidogrel 300 mg then 75 mg OD

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9
Q

NSTEACS: high risk of mortality or recurrent CS event (STAT) P2Y12 inhibitor

A

Clopidogrel 300-600 mg the 75 mg OD

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10
Q

NSTEACS: high risk of mortality or recurrent CS event (STAT) IV anticoagulation

A

Enoxaparin
CrCl >/=30 mL/min 1 mg/kg subcut BD
CrCl < 30 1 mg/kg subcut OD (or unfractionated heparin if kidney failure or high bleeding risk 60 U/kg then 12 U/kg/hour

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11
Q

NSTEACS: high risk of mortality or recurrent CS event (STAT) Betablocker

A

Atenolol 25 mg up to 100 mg OD

Metoprolol 25 mg BD to 100 mg BD

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12
Q

NSTEACS: intermedicate risk of mortality or recurrent CVS event

A

Aspirin
OR
P2Y12 Inhibitor

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13
Q

NSTEACS: Low risk of mortality or recurrent CVS event

A

Aspirin

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14
Q

Long term ACS antiplatelet

A

Aspirin 75-100 mg OD
AND
Clopidogrel 75 mg OD (for 1 year)

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15
Q

Long term ACS Betablocker

A

Atenolol 25 mg to 100 mg OD
Metoprolol 25 to 100 mg BD
for 1-3 years

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16
Q

COPD exacerbation: Bronchodilator

A

Salbutamol 100 mcg up to 10 times (Q3hr)
OR/AND

Terbutaline 500 mcg 1-2 times
OR
Ipratropium 21 mcg up to 6 times

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17
Q

COPD exacerbation: Oral corticosteroids

A

Prednisone 30 to 50 mg PO OD mane 5/7

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18
Q

COPD exacerbation: Antibiotics

A
Avoid augmentin
Amoxicillin 500 mg PO Q8h 5/7
OR
Amoxicillin 1g PO Q12h 5/7
OR 
Doxycylin 100 mg PO OD 5/7
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19
Q

Post operative Nausea and vomiting: No prophylaxis given

A

5-HT3–receptor antagonist: Ondansetron 1-4 mg

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20
Q

Post operative Nausea and vomiting: Prophylaxis given

A

Dexamethasone 2-4 mg IV
OR
Droperidol 0.625 mg IV

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21
Q

Acute Pulmonary Oedema: GP setting

A
Furosemide
20-80 mg
IV/IM
Q20 min
(+/- high flow O2)
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22
Q

Acute Pulmonary Oedema: GP setting (if first line ineffective)

A

Add GTN 400 micrograms sublingual spray Q5min Max 1200 mcg
OR
GTN tablet subling 300-600 mcg Q5min max 1800 mcg
MIND BP

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23
Q

Acute Pulmonary Oedema ED/CCU: First line

A

Furosemide 20-80 mg IV Q20 min

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24
Q

Acute Pulmonary Odema ED/CCU Addition to first line

A

GTN infusion
10 mcg/minute IV
Double the rate Q5min according to response

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25
Q

Acute Pulmonary Oedema: Anxiety

A

Morphine 1-2.5 mg IV once only

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26
Q

Acute Pulmonary Oedema: AF

A

Amiodarone 300 mg IV over 30-60 minutes

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27
Q

Acute Pulmonary Oedema: No response to first line management

A

Dobutamine 2.5-15 mcg/kg/minute IV

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28
Q

Valvular Atrial Fibrillation Stroke prevention

A

Warfarin

dose targeted to INR

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29
Q

Non-valvular AF Factor Xa inhibitor (CrCl >/= 25 mL/min, No bleeding risk factors)

A

Apixaban
5mg
PO
BD

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30
Q

Non-valvular AF Factor Xa inhibitor (CrCl >/= 25 mL/min, >/= 2 bleeding risk factors)

A

Apixaban
2.5mg
PO
BD

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31
Q

Non-valvular AF Factor Xa inhibitor (CrCl >/= 50mL/min)

A

Rivaroxaban
20 mg
PO
OD

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32
Q

Non-valvular AF Factor Xa inhibitor (CrCl 30-49 mL/min)

A

Rivaroxaban
15mg
PO
OD

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33
Q

Non-valvular AF direct thrombin inhibitor
Age < / = 75
CrCL >/=50

A

Dabigatran
150mg
PO
BD

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34
Q

Non-valvular AF direct thrombin inhibitor
Age < / = 75
CrCL 30-50 mL/min OR increased bleed risk

A

Dabigatran
110mg
PO
BD

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35
Q

Non-valvular AF direct thrombin inhibitor
Age >/= 75
CrCL >/=30

A

Dabigatran
110 mg
PO
BD

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36
Q

Parentral Iron (Ferinject) IV injection

A

Ferinject=ferric carboxymaltose
Max 1000 mg per week
IV injection: slow infusion (100mg/min)

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37
Q

Parentral Iron (Ferinject) IV infusion

A
Ferinject=ferric carboxymaltose
Max 1000 mg per week
IV infusion 200-500 mg in 100mL NaCl
over 6 minutes
500-1000mg  in 250 mL NaCl
over 15 minutes
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38
Q

Parentral Iron (Ferrosig,Ferrum H)

A

Iron Polymaltose
1000 mg
over 5 hours

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39
Q

COPD Exacerbation IV corticosteroid

A

Hydrocortisone
100 mg
IV
Q6h

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40
Q

Long term ACS: ACEi indications

A

If LV failure or dysfunction, Previous MI, DM, HTN, Anterior infarct, elevated HR

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41
Q

Long term ACS: Aldosterone antagonists indications

A

LV dysfunction, heart failure, DM

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42
Q

Medications to avoid in Heart failure

A
  • NSAIDs (COX2 inhibitors)
  • Corticcosteroids
  • negative inotropes (verapamil,diltiazem)
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43
Q

Principles of HFrEF management

A

1) ACEI/ARB + BB
2) ACEI/ARB + BB +Aldosterone antagonist
3) Switch ACEI/ARB for ARNI
4) Add loop diuretic for symptom control as needed- titrate to effect
5) Symptoms of hypotension- reduced the ACEI/ARB first
6) Switch patients taking other BB to cardiac BB

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44
Q

ACEI Side effects

A
  • Hypotension
  • Renal impairement
  • Hyperkalaemia
  • Dry cough
  • Angiooedema
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45
Q

ARB side effects

A
  • Hypotension
  • Renal impairement
  • Hyperkalaemia
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46
Q

Aldosterone antagonist side effects

A

-Severe hyperkalaemia when using in kidney impairement

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47
Q

Beta blocker principles

A
  • Not to start until stable and euvolemic

- Start at lowest dose and double every 2-4 weeks

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48
Q

HFrEF ACEIs

A

Captopril 6.25 mg tdx to 75 mg BD

Enalapril 2.5 mg PO OD to 20 mg OD

Lisinopril 2.5 mg PO OD to 40 mg OD

Perindopril erbumine 2 mg PO OD to 8 mg OD

Quinapril 5 mg PO OD to 20 mg OD

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49
Q

HFrEF ARBs

A

Candesartan 4 mg PO OD to 32 mg OD

Losartan 25 mg PO OD to 100 mg OD

Valsartan 40 mg PO BD to 160 mg BD

Irbesartan 75 mg PO OD to 300 mg OD

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50
Q

HFrEF BBs

A

Bisoprolol 1.25 mg to 10 mg OD

Carvedilol <85 kg 3.125 mg PO BD to 25 mg BD;
>85 kg 3.125mg PO BD to 50 mg BD

Metoprolol SR 23.75 mg OD to 190 mg OD

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51
Q

HFrEF Aldosterone antagonsts

A

Eplerenone 25 mg PO OD to 50 mg

Spironolactone 25 mg PO OD to 50 mg

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52
Q

HFrEF Loop Diurectis

A

Furosemide 20-40 mg PO OD

Bumetinide 0.5- 1 mg PO OD

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53
Q

HFrEF ARNI

A

Sacubitril 49 mg PO BD + Valsartan 51 mg PO BD
increase dose every 2-4 weeks to
Sacubitril 97 mg PO BD + Valsartan 103 mg BD

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54
Q

DKA Fluids BP >90 mmHg systolic

A

0.9% Sodium Chloride

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55
Q

DKA Fluid BP <90 mmHg systolic

A

0.9% sodium chloride over 10 to 15 minutes

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56
Q

DKA Insulin

A

Soluble insulin in 0.9% NaCl (1 unit/mL)

Infuse at 0.1 unit/kg/hour

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57
Q

Principles of Hypertension management

A
1) start with a single drug
ACEI (HFrEF, kidney disease)
ARB
CCB (angina)
Thiazide 
Patients over 55 or of African/Caribbean descent: Thiazide/CCB first line
2)BP goal not met add the second drug of different class
3)increase the dose of one drug
4) increase the dose of the second drug
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58
Q

ACEI for hypertension

A
Captopril 12.5-50 mg BD
Enalapril 5-40 mg OD
Lisinopril 5-40 mg OD
Quinapril 5-40 mg
Perindoril 4-8 mg
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59
Q

ACEI Cautions

A

Hypotension
Kidney impairment
Hyperkalemia

60
Q

ARBs for Hypertension

A

Candesartan 8-32 mg
Irbesartan 150-300 mg
Losartan 50-100 mg

61
Q

ARB’s cautions

A

Hypotension, Kidney impairment, hyperkalemia

62
Q

CCB for hypertension

A

Amlodipine 5-10 mg OD
Felodipine MR 5-20 mg OD
Nifedipine MR 20-120 mg OD

63
Q

Cautions for CCB

A

Peripheral oedema (due to redistribution, not fluid retention)

64
Q

Thiazide for hypertension

A

Chlorthalisone 12.5 mg to 25 mg OD

Indapamide 1.25-2.3 mg OD

65
Q

Thiazide cautions

A

Not to be used first-line for under 65-year-olds due to risk of DM
Avoid in gout
Avoid in metabolic syndrome

66
Q

Principles of VTE prophylaxis

A

1) LMWH is prefered over UFH
2) UFH for patients with severe kidney impairment or likely to need a rapid reversal
3) Hip or knee replacement: rivaroxaban, dabigatran, apixaban
4) If patients have a history of HITT do not use heparin
5) If patients have low platelets don’t use pharmacological prophylaxis
6) Patients already on anticoagulation don’t need extra VTE prophylaxis
7) Patients can continue antiplatelets but need additional VTE prophylaxis
8) Patients on Warfarin with INR >2 should not be given prophylactic heparin

67
Q

LMWH for VTE prophylaxis

CrCL >30 mL/min

A

Dalteparin 5000 units SC OD

Enoxaprin 40 mg SC OD

68
Q

LMWH for VTE prophylaxis

CrCL <30 mL/min

A

Enoxaparin 20 mg SC OD

69
Q

Unfractionated heparin for VTE prophylaxis

A

5000 U SC Q8-12h

70
Q

VTE prophylaxis following hip/knee surgery

CrCL >50 mL/min

A

Dabigatran
110 mg 1-4 hours after
220 mg OD

71
Q

VTE prophylaxis following hip/knee surgery

CrCL 30-50 mL/min

A

Dabigatran
75 mg 1-4 hours after
150 mg OD

72
Q

VTE prophylaxis following hip/knee surgery

CrCL > 25 mL/min

A

Apixaban

2.5 mg PO BD

73
Q

VTE prophylaxis following hip/knee surgery

CrCL >15 mL/min

A

Rivaroxaban 10 mg PO OD

74
Q

LMWH cautions

A

Renaly cleared

75
Q

Heparin cautions

A

Heparin-induced thrombotic thrombocytopenia

76
Q

Digoxin caution

A

Renaly cleared

77
Q

Metformin caution

A

withhold in acute illness/renal impairment

contraindicated when crCL<30 ml/min

78
Q

Benzodiazepines in elderly caution

A

Benzodiazepines are not to be used first-line in elderly

79
Q

Risk of digoxin toxicity

A

Hypokalaemia
Hypomagnesemia
Hypercalcemia
Hypoxia

80
Q

Indications for emergent cardioversion in AF

A

Active ischemia
Shock or hypoperfusion
Severe heart failure
hypotension where other measures have failed

81
Q

The first-line goal for new AF

A

Rate control

82
Q

Indications for anticoagulation prior to cardioversion in AF

A

If AF for >48 hours

If the duration of AF is unknown

83
Q

Emergent Treatment for AF (indications and options)

A

Clinically or hemodynamically unstable

IV rate control or cardioversion

84
Q

Urgent treatment for AF (indications and options)

A

Symptomatic but stable

IV rate control

85
Q

Rate control in AF

A

Preferred where >48 hours or if uncertain duration of onset
1) Beta-blockers (Metoprolol,)
CCB (verapamil and diltiazem)
2) Digoxin when the rate is not controlled by BB or CCB or if heart failure with AF

86
Q

STEMI algorithm

A

1) ABC and O2 15L by nonrebreather (unless COPD)
2) History, exam, investigations and diagnose
3) Aspirin 300 mg oral
4) Morphine 5-10 mg IV with Metoclopramide 10 mg IV
5) GTN stray/tablet
6) PCI/thrombolysis
7) Beta-blocker unless LVF or asthma for 3 years

87
Q

NSTEMI algorithm

A

1) ABC and O2 15L by nonrebreather (unless COPD)
2) History, exam, investigations and diagnose
3) Aspirin 300 mg oral
4) Morphine 5-10 mg IV with Metoclopramide 10 mg IV
5) GTN stray/tablet
6) clopidogrel 300 mg oral or LMW Heparin for 48 hours/till cardiac catheterisation
7) Beta-blocker unless LVF or asthma for 3 years

88
Q

Acute LV Failure algorithm

A
ABC and O2 15 L by non-rebreather unless COPD
History, exam investigations
Sit patient up
Morphine 5-10 mg IV with metoclopramide 10 mg IV
GTN spray/tablet
Furosemide 40-80 mg IV
if inadequate response 
Isosorbide dinitrarte infusion +/- CPAP
89
Q

Torsade de pointes management

A

Magnesium sulfate 2g over 10 minutes

90
Q

VT management

A

Amiodarone 300 mg IV over 20-60 minutes

then 900 mg over 24 hours

91
Q

Narrow complex regular tachycardia

A

1) vagal maneuvers
2)Adenosine 6 mg rapid, if unsuccessful
12 mg, if unsuccessful
give 12 mg

92
Q

Narrow complex irregular tachycardia

A

Possibly AF
give BB or diltiazem
consider digoxin/amiodarone if evidence of HF

93
Q

Anaphylaxis algorithm

A
ABC and 15L O2 via rebreather
History and exam
Remove cause
Adrenaline 500 mcg of 1:1000 IM (Q5 min)
Hydrocortisone 200 mg IV
Continuing respiratory deterioration: IV bronchodilators
94
Q

Acute exacerbation of asthma/COPD algorithm

A

ABC
Hx and Exam
100% (28% for COPD) O2 by nonrebreather
Salbutamol 5 mg nebs Q20 min for up to an hour/6-12 puffs Q10-20 min
Hydrocortisone 100 mg IV (if severe/life-threatening)
OR prednisone 40 mg oral (if moderate) (5 days)
Ipratropium 6 puffs via spacer Q20 or 500mcg nebs Q4-6h
IV Magnesium sulfate
IV aminophylline (only in life-threatening)

95
Q

Secondary Pneumothorax management

A

Aspirate unless:

>2 cm, SOB or >50 yo - chest drain

96
Q

Tension pneumothorax management

A

emergency aspiration and chest drain

97
Q

Primary pneumothorax management

A

<2cm and not SOB discharge with follow up in 4 weeks

> 2cm or SOB aspirate, if unsuccessful aspirate again and if unsuccessful again then chest drain

98
Q

Assessment of Community-acquired pneumonia

A
CURB 65
Confusion
Urea >7.5 
Resp rate >30 
BB (systolic) <90 
Age >65
99
Q

Pneumonia Algorithm

A
ABC
Hx Ex
High flow oxygen
Antibiotics
paracetamol
IV fluids if low BP or raised HR
100
Q

Pulmonary embolism algorithm

A
ABC
Hx Ex Ix
High flow oxygen
Morphine 5-10 mg Iv with 10 mg metoclopramide
LMWH 
if low BP give colloid
101
Q

GI bleeding algorithm

A
The 8 Cs
ABC and O2 15 L
Hx, Ex, Ix
2 large bore Cannulae
Catheter and strict fluid monitoring 
Crystalloid if normal BP 
Cross matched 6 units of blood
Correct clotting abnormalities (FFP/prothrombinex in warfarised/ platelets if low)
Camera- Endoscopy
Stop Culprit drugs (NSAID, Aspirin, warfarin, heparin)
102
Q

Bacterial meningitis algorithm

A
ABC
History, exam investigations
high flow oxygen
IV fluids
Dexamethasone unless immunocompromised
LP +/- CT
2g ceftriaxone IV
103
Q

Seizures algorithm

A

ABC (may need an airway)
recovery position
History and investigations (provoking factors)

104
Q

A seizure lasting more than 5 minutes algorithm

A

Lorazeoam 2-4mg IV OR
10 mg Diazepam IV OR
10 mg Midazolam buccal

Still fitting after 2 minutes
repeat diazepam
inform anesthetics
Phenytoin infusion
Intubate then propofol
105
Q

Stroke algorithm

A

ABC
History, exam, investigations (including Blood glucose and CT head to exclude hemorrhage)
If <80 and onset <4.5 hours ago consider thrombolysis
Aspirin 300 mg

106
Q

DKA algorithm

A
ABC
history, exam, investigation
IV fluids: 1L stat then
1L over 1 hour
then 2 hours
then 4 hours
then 8 hours
Sliding scale insulin
find trigger
monitor K, glucose, and pH
107
Q

Hypoglycemia algorithm

A

If able to eat give a sugar-rich snack like orange juice or biscuits (10-20g glucose)
Unable to eat: IV glucose: 100 mL 20% glucose
IM glucagon 1 mg in unconscious patients with no IV access

108
Q

Acute Kidney Injury algorithm

A
ABC
History and exam 
Cannula, catheter, and strict fluid monitoring
IV 500 mL stat
1L 4 hourly
look for cause and complications
Monitoring U&amp;Es and fluid balance
109
Q

When to treat hypertension

A

BP >150/95 or

> 135/85 if coexisting:
vascular disease
Hypertensive organ damage

110
Q

Target blood pressures for <80 yo

A

<140/85 (<135/85 at home)

111
Q

Target blood pressure in patients over 80

A

add 10 mmHg to systolic values

112
Q

CHA2DS2 VASc

A
Congestive heart failure
Hypertension
Age >75 (2 points)
Diabetes mellitus
Stroke or TIA previously (2 points)
Vascular disease 
Age 65-74
Sex (female)
113
Q

Indications for rhythm control in AF

A

Young
symptomatic AF
First episode
AF due to a treated precipitant

114
Q

Methods for rhythm control in AF

A

Cardioversion
Electrical (with need anticoagulation if more than 48 hrs from onset)
Amiodarone 5 mg/kg IV over 20-120 minutes

115
Q

Stable angina algorhithm

A

1) PRN GTN spray
secondary prevention: aspirin, statin, etc
one antianginal drug depending on contraindications (BB or CCB)
2)increase BB or CCB dose
3)Add long-acting nitrate or potassium channel activator
4)Refer for PCI or CABG

116
Q

Chronic Asthma Algorithm

A

1) SABA (salbutamol)
2) Add inhaled steroid 200-800 mcg (starting at 400 mcg) (e.g beclomethasone)
3) Add inhaled LABA (salmeterol or formoterol) and asses control

Good response- continue
Benefit but still inadequate control- continue LABA and increased inhaled steroid dose to 800 mcg
No response to LABA- stop LABA and increase IHCS dose to 800 mcg and trial other therapies

Trail: increased ICS to 2000 mcg/day
Add forth drug leukotriene receptor antagonist/ SR theophylline/omalizumab/tiotropium

Low dose daily steroid with high dose ICS at 2000 mcg

117
Q

Type 2 DM Algorhitm

A

1) If overweight Metformin 500 mg UNLESS
-low weight
-Creatinine >150
use Gliclazide 40 mg
2)If HbA1c >48 then increase dose to maximum
3) If HbA1c still >48 :
-Metformin add sulphonylurea
-Sulphonylurea add gliptin
4) If HbA1c still >48 add insulin

118
Q

COPD first line

A

SABA or SAMA PRN

119
Q

COPD when FEV1 >50

A
After PRN SAMA/SABA
1)LABA or
LAMA (and discontinue SAMA)
2) LABA+ICS (or LABA+LAMA)
3)LAMA+LABA+ICS
120
Q

COPD when FEV1<50

A

PRN SAMA/SABA
1)LABA+ICS (or LABA+LAMA) or
LAMA (discontine SAMA)
2)LAMA+LABA+ICS

121
Q

First-line for epilepsy with focal seizures

A

Carbamazepine

Lamotrigine

122
Q

First-line for epilepsy with generalized Tonic-clonic seizures

A
Sodium Valproate (avoid in women of childbearing age)
Lamotrigine
123
Q

First-line for epilepsy with generalized absence seizures

A
Ethosuximide 
Sodium valproate (avoid in women of childbearing age)
124
Q

First-line for epilepsy with generalized Myoclonic seizures

A

Sodium valproate
Topiramate
Levetiracetam

125
Q

First-line for epilepsy with generalized Tonic and atonic seizures

A

Sodium valproate

126
Q

Treatment of IBD flare

A

1) local aminosalicylate/local corticosteroid
2) local aminosalicylate+ local corticosteroid
3) oral aminosalicylate
4) add oral prednisone or MR budesonide (Crohn’s affecting ileum/colon)
5) Hydrocortisone 100 mg Q6h IV

127
Q

Maintaining remission in IBD

A

Azathioprine

6-mercaptopurine

128
Q

Management of Rheumatoid arthritis

A

Methotrexate + DMARD

129
Q

Management of Rheumatoid arthritis flare

A

Short term glucocorticoids

Short term NSAIDs

130
Q

Managing fever

A

Paracetamol

131
Q

Chronic non-infectious diarrhea management

A

loperamide 2 mg up to 3 hourly

Codeine 30 mg up to 6 hourly

132
Q

Management of Insomnia where sleep hygiene and conservative measures are ineffective

A

Zopiclone 7.5 mg nocte

3.75 mg nocte in elderly

133
Q

Pharmaceutical cardioversion in AF

A

1) Flecainide

Amiodarone

134
Q

Chronic asthma standard dose ICS and doses

A

Beclamethasone dipropionate 400-500 mcg/day
(Qvar is beclamethasone dipropionate extrafine= 200 mcg/day_
Budesonide 400 mcg/day
Fluticasone propionate 200-250 mcg/day

135
Q

Hyperkalaemia algorithm

A

1)Insulin and dextrose- actarapid or novorapid
10 units actarapid in 100 mL 20% dextrose over 30 minutes
1) Calcium gluconate
2) salbutamol
3) Calcium resonium

136
Q

Antiepileptics in pregnancy

A

Lamotrigine has best saftey profile

137
Q

Dyspepsia

A

Start with antacids such as Magnesium carbonate, aluminium hydroxide etc for quick relief
PPIs and H2 antagonists take longer to act

138
Q

Management of short duration constipation

A

bulk-forming laxatives unless symptomatic

139
Q

Management of constipation with difficulty passing a soft stool

A

Stimulant e.g. senna

140
Q

Constipation with hard stool

A

Stool softener e.g. docusate

141
Q

Opioid-induced constipation

A

osmotic
stimulant
bulk-forming should be avoided

142
Q

Contraindications to osmotic laxatives

A

bloating

143
Q

Hypercalcaemia of malignancy

A

Zoledronic acid, Pamidronate

care that patients are adequately hydrated

144
Q

Roundworm, threadworm

A

Mebendazole

145
Q

Inducing remission in patients with ileocecal Crohn’s disease

A

budesonide when glucocorticoid is contraindicated