Treatment algorhtytms (including NPC) Flashcards
Peptic Ulceration with H.Pylori (PPI)
esomeprazole 20 mg PO bd 7/7
Peptic Ulceration with H.Pylori (Abx)
Amoxicillin 1 g PO BD 7/7
Peptic Ulceration with H.Pylori (Abx 2)
Clarithromycin 500mg PO BD 7/7
Peptic Ulceration with H.Pylori (penecillin allergy)
Metronidazole 400 mg PO BD 7/7
Oral iron supplementation
Elemental iron 100 to 210 mg
PO
OD
STEMI: high risk of mortality or recurrent cardiovascular event (STAT) Antiplatelet
Aspirin 300 mg PO then 100-150mg OD
NSTEACS: high risk of mortality or recurrent CS event (STAT) Antiplatelet
Aspirin 300 mg PO the 100-150 mg OD
STEMI: high risk of mortality or recurrent cardiovascular event (STAT) P2Y12 inhibitor
PCI: clopidogrel 600 mg then 75 mg OD
Fibrinolysis: clopidogrel 300 mg then 75 mg OD
NSTEACS: high risk of mortality or recurrent CS event (STAT) P2Y12 inhibitor
Clopidogrel 300-600 mg the 75 mg OD
NSTEACS: high risk of mortality or recurrent CS event (STAT) IV anticoagulation
Enoxaparin
CrCl >/=30 mL/min 1 mg/kg subcut BD
CrCl < 30 1 mg/kg subcut OD (or unfractionated heparin if kidney failure or high bleeding risk 60 U/kg then 12 U/kg/hour
NSTEACS: high risk of mortality or recurrent CS event (STAT) Betablocker
Atenolol 25 mg up to 100 mg OD
Metoprolol 25 mg BD to 100 mg BD
NSTEACS: intermedicate risk of mortality or recurrent CVS event
Aspirin
OR
P2Y12 Inhibitor
NSTEACS: Low risk of mortality or recurrent CVS event
Aspirin
Long term ACS antiplatelet
Aspirin 75-100 mg OD
AND
Clopidogrel 75 mg OD (for 1 year)
Long term ACS Betablocker
Atenolol 25 mg to 100 mg OD
Metoprolol 25 to 100 mg BD
for 1-3 years
COPD exacerbation: Bronchodilator
Salbutamol 100 mcg up to 10 times (Q3hr)
OR/AND
Terbutaline 500 mcg 1-2 times
OR
Ipratropium 21 mcg up to 6 times
COPD exacerbation: Oral corticosteroids
Prednisone 30 to 50 mg PO OD mane 5/7
COPD exacerbation: Antibiotics
Avoid augmentin Amoxicillin 500 mg PO Q8h 5/7 OR Amoxicillin 1g PO Q12h 5/7 OR Doxycylin 100 mg PO OD 5/7
Post operative Nausea and vomiting: No prophylaxis given
5-HT3–receptor antagonist: Ondansetron 1-4 mg
Post operative Nausea and vomiting: Prophylaxis given
Dexamethasone 2-4 mg IV
OR
Droperidol 0.625 mg IV
Acute Pulmonary Oedema: GP setting
Furosemide 20-80 mg IV/IM Q20 min (+/- high flow O2)
Acute Pulmonary Oedema: GP setting (if first line ineffective)
Add GTN 400 micrograms sublingual spray Q5min Max 1200 mcg
OR
GTN tablet subling 300-600 mcg Q5min max 1800 mcg
MIND BP
Acute Pulmonary Oedema ED/CCU: First line
Furosemide 20-80 mg IV Q20 min
Acute Pulmonary Odema ED/CCU Addition to first line
GTN infusion
10 mcg/minute IV
Double the rate Q5min according to response
Acute Pulmonary Oedema: Anxiety
Morphine 1-2.5 mg IV once only
Acute Pulmonary Oedema: AF
Amiodarone 300 mg IV over 30-60 minutes
Acute Pulmonary Oedema: No response to first line management
Dobutamine 2.5-15 mcg/kg/minute IV
Valvular Atrial Fibrillation Stroke prevention
Warfarin
dose targeted to INR
Non-valvular AF Factor Xa inhibitor (CrCl >/= 25 mL/min, No bleeding risk factors)
Apixaban
5mg
PO
BD
Non-valvular AF Factor Xa inhibitor (CrCl >/= 25 mL/min, >/= 2 bleeding risk factors)
Apixaban
2.5mg
PO
BD
Non-valvular AF Factor Xa inhibitor (CrCl >/= 50mL/min)
Rivaroxaban
20 mg
PO
OD
Non-valvular AF Factor Xa inhibitor (CrCl 30-49 mL/min)
Rivaroxaban
15mg
PO
OD
Non-valvular AF direct thrombin inhibitor
Age < / = 75
CrCL >/=50
Dabigatran
150mg
PO
BD
Non-valvular AF direct thrombin inhibitor
Age < / = 75
CrCL 30-50 mL/min OR increased bleed risk
Dabigatran
110mg
PO
BD
Non-valvular AF direct thrombin inhibitor
Age >/= 75
CrCL >/=30
Dabigatran
110 mg
PO
BD
Parentral Iron (Ferinject) IV injection
Ferinject=ferric carboxymaltose
Max 1000 mg per week
IV injection: slow infusion (100mg/min)
Parentral Iron (Ferinject) IV infusion
Ferinject=ferric carboxymaltose Max 1000 mg per week IV infusion 200-500 mg in 100mL NaCl over 6 minutes 500-1000mg in 250 mL NaCl over 15 minutes
Parentral Iron (Ferrosig,Ferrum H)
Iron Polymaltose
1000 mg
over 5 hours
COPD Exacerbation IV corticosteroid
Hydrocortisone
100 mg
IV
Q6h
Long term ACS: ACEi indications
If LV failure or dysfunction, Previous MI, DM, HTN, Anterior infarct, elevated HR
Long term ACS: Aldosterone antagonists indications
LV dysfunction, heart failure, DM
Medications to avoid in Heart failure
- NSAIDs (COX2 inhibitors)
- Corticcosteroids
- negative inotropes (verapamil,diltiazem)
Principles of HFrEF management
1) ACEI/ARB + BB
2) ACEI/ARB + BB +Aldosterone antagonist
3) Switch ACEI/ARB for ARNI
4) Add loop diuretic for symptom control as needed- titrate to effect
5) Symptoms of hypotension- reduced the ACEI/ARB first
6) Switch patients taking other BB to cardiac BB
ACEI Side effects
- Hypotension
- Renal impairement
- Hyperkalaemia
- Dry cough
- Angiooedema
ARB side effects
- Hypotension
- Renal impairement
- Hyperkalaemia
Aldosterone antagonist side effects
-Severe hyperkalaemia when using in kidney impairement
Beta blocker principles
- Not to start until stable and euvolemic
- Start at lowest dose and double every 2-4 weeks
HFrEF ACEIs
Captopril 6.25 mg tdx to 75 mg BD
Enalapril 2.5 mg PO OD to 20 mg OD
Lisinopril 2.5 mg PO OD to 40 mg OD
Perindopril erbumine 2 mg PO OD to 8 mg OD
Quinapril 5 mg PO OD to 20 mg OD
HFrEF ARBs
Candesartan 4 mg PO OD to 32 mg OD
Losartan 25 mg PO OD to 100 mg OD
Valsartan 40 mg PO BD to 160 mg BD
Irbesartan 75 mg PO OD to 300 mg OD
HFrEF BBs
Bisoprolol 1.25 mg to 10 mg OD
Carvedilol <85 kg 3.125 mg PO BD to 25 mg BD;
>85 kg 3.125mg PO BD to 50 mg BD
Metoprolol SR 23.75 mg OD to 190 mg OD
HFrEF Aldosterone antagonsts
Eplerenone 25 mg PO OD to 50 mg
Spironolactone 25 mg PO OD to 50 mg
HFrEF Loop Diurectis
Furosemide 20-40 mg PO OD
Bumetinide 0.5- 1 mg PO OD
HFrEF ARNI
Sacubitril 49 mg PO BD + Valsartan 51 mg PO BD
increase dose every 2-4 weeks to
Sacubitril 97 mg PO BD + Valsartan 103 mg BD
DKA Fluids BP >90 mmHg systolic
0.9% Sodium Chloride
DKA Fluid BP <90 mmHg systolic
0.9% sodium chloride over 10 to 15 minutes
DKA Insulin
Soluble insulin in 0.9% NaCl (1 unit/mL)
Infuse at 0.1 unit/kg/hour
Principles of Hypertension management
1) start with a single drug ACEI (HFrEF, kidney disease) ARB CCB (angina) Thiazide Patients over 55 or of African/Caribbean descent: Thiazide/CCB first line 2)BP goal not met add the second drug of different class 3)increase the dose of one drug 4) increase the dose of the second drug
ACEI for hypertension
Captopril 12.5-50 mg BD Enalapril 5-40 mg OD Lisinopril 5-40 mg OD Quinapril 5-40 mg Perindoril 4-8 mg