Transport of O2 and CO2 Flashcards

1
Q

Four types of hypoxia and examples

A

Histotoxic- cyanide toxicity
Hypoxic- COPD
Anemic-
Stagnant- low CO, PVD

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2
Q

Normal HGB level

A

15g/dL

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3
Q

How much of the o2 does hgb hold?

A

65x more than plasma

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4
Q

HGB composition

A

2 a 2 b= 4 subunits
Normal adult- HbA=a2b2

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5
Q

How much o2 can a gram of hgb hold?

A

1.34ml

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6
Q

What is oxygen saturation?

A

Ratio of oxygen bound hgb compared to total amount that can be saturated

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7
Q

Saturation and PaO2

A

100-100
95-75
90-60
70-40
50-27

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8
Q

CO affinity to HGB

A

250x more than oxygen
Does not dissociate readily, takes hours to ride CO from body

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9
Q

N2O

A

Binds hgb 200,000 more strongly than o2
Bind irreversably
For PH

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10
Q

What decreases hgb affinity to o2

A

BHOR BYE O2
hyperthermia
acidosis
2,3 DPG

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10
Q

What increases hgb o2 affinity

A

HALDANE HOLDS O2
Hypothermia
Alkalosis
Low 2,3 DPG
blood transfusions
Carboxyhemoglobin/methemoglobin

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11
Q

DO2 formula

A

cao2 x co x 10

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11
Q

CaO2 formula

A

(1.34 x hgb x sao2) + (pao2 x .003)

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12
Q

CO2 production /min

A

200ml/min
Exercise increases 6x

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13
Q

Normal Co2 production and O2 consumption

A

CO2 production- 200ml/min
O2 consumption- 250ml/min

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14
Q

AV difference for O2 and CO2

A

O2- 50ml/L (90-40)
CO2- 40ml/L (40 in vein 0 in artery)

15
Q
A