Renal 2 Don Flashcards

1
Q

MALTS

A

Mannitol PCT
Acetazolamide PCT
Loop diuretics LOH
Thiazide diuretics DCT
Spironolactone CD

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2
Q

Normally, selective permeability permits approximately ___ of plasma elements to pass into the bowmans capsule, cells and proteins more than 60kDa ___

A

25%
Can not pass

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3
Q

The basement membrane is ____ charged due to ___ which composes it. ___ charged proteins are thus repelled and are unable to pass thru it.

A

Negatively
glycoproteins
Negatively

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4
Q

The two major determinants of filtration pressure are ___ and ___

A

glomerular capillary pressure (Pgc)
glomerular oncotic pressure (Pgc)

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5
Q

Normal GFR is ___, AKA ___ per day

A

120ml/ min
180L/ day

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6
Q

The vasa recta descends _____

A

Deep into the medulla, parallel to the LOH.

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7
Q

RBF is about ___ of CO

A

20%
2nd to only the liver

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8
Q

The vast majority of what is filtered is ___

A

reabsorbed

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9
Q

High hydrostatic pressure in the glomerular capillaries (60mmHg) causes ___

A

Rapid fluid filtration

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10
Q

Lower hydrostatic pressure in the peritubular capillaries (13mmHg) causes ___

A

rapid reabsorption

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11
Q

What are the factors that determine GFR?

A

1- ultrafiltration coefficient (cap permeability)
2- glomerular oncotic pressure (no protein, so direction should oppose filtration)
3- glomerular capillary pressure ( controlled by afferent and efferent arterioles)
4 capillary plasma flow rate

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12
Q

Formula for net filtration pressure-

A

Normal- 10mmHg
glomerular hydrostatic pressure- bowmans capsule pressure - glomerular oncotic pressure

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13
Q

What determines the glomerular hydrostatic pressure?

A

Arterial pressure- Increase MAP increases GFR, autoregulation
Afferent arteriolar resistance- Constriction reduces GFR, dilation increases GFR
Efferernt arteriolar resistance- constriction is biphasic- mild constriction increases GFR, excessive constriction reduces RBF and GFR, dilation reduces GFR

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14
Q

Most important factor of GFR

A

Glomerular hydrostatic pressure
(per apex, not even in dons top 4)

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15
Q

GFR is autoregulated between what pressures?

A

SBP 80-200

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16
Q

GFR is autoregulated by what 2 mechanisms?

A

Constriction/ dilation of afferent and efferent arterioles
Increased Na delivery to the macula densa will decrease GFR via adenosine induced vasoconstriction of the afferent arteriole

17
Q

What is the macula densa

A

Specialized group of epithelial cells in the distal tubules
contains the golgi apparatus which secretes substances towards the arterioles

18
Q

Decreased Na affects the macula densa by ___ and ___

A

1- drops resistance and increases GFR
2- Increases renin release from JG cells of the afferent and efferent arterioles, end product is increased GFR

19
Q

If a substance is completely reabsorbed, then the clearance is ___

A

0

20
Q

Renal function compared to % of functioning nephrons and GFR

A

normal renal- 100% function, 120ml/min
Reduced renal- 10-40% function, 10-80 ml/min
Renal failure- <10% function, <12ml/min

21
Q

What are the 3 mechanisms of reabsorption and secretion?

A