Transport Mg, Calcium, Phosphorus

Question 1

What catalyzes formation of urate?

Answer 1

Xanthine oxidase

Question 2

What uptakes urate apical side?

Answer 2

URAT1

OAT4

Question 3

What uptakes urate basolateral side?

Answer 3

OAT1/3

GLUT9

Question 4

What drugs inhibit URAT1 and OAT4?

Answer 4

URAT1: Probenecid, benzbromarone, sulfinpyrazone
OAT4: Sulfinpyrazone

Question 5

What drugs inhibit GLUT9 and OAT1/3?

Answer 5

Probenecid

Benzbromarone

Question 6

Mechanism of gout?

Answer 6

Monosodium urate taken up by macrophages and they release IL-1Beta causing inflammation

Question 7

What pumps phosphate across apical side

Answer 7

Na/Pi-IIa

Question 8

What pumps phosphate across basolateral side

Answer 8

Na/Pi Type III

Question 9

Apical Ca2 PCT/DCT

Answer 9

Calcium channels

Question 10

Basolateral Ca2 PCT/DCT

Answer 10

Na/Ca exchange

Question 11

Apical Ca2 TAL

Answer 11

Calcium channels

Question 12

Basolateral Ca2 TAL

Answer 12

PMCA

Na/Ca

Question 13

How does Mg move across the apical membrane

Answer 13

Ca2 sensing receptor senses Ca and transports Mg2 across

Question 14

What protein is needed for Mg diffusion through tight junctions?

Answer 14

Paracellin-1 protein