Antibiotics I Flashcards
What are 3rd generation cephalosporins used to treat?
Some gram + more so gram - cocci
Aminoglycosides:
Streptomycin
Kanamycin
Neomycin
Gentamicin
Amikacin
What are the two general categories of DNA topoisomerases?
Quinolones
Fluoroquinolones
Miscellaneous cell wall inhibitors:
Bacitracin
What are 2nd generation cephalosporins used to treat?
Gram + cocci and some gram -
Tetracyclines:
Doxycycline
Minocycline
Tetracycline
What are penicillin 1st generation drugs?
Benzyl penicillin (oral) Penicillin V (oral)
Two categories of 50s ribosomal subunit binders:
Macrolides
Chloramphenicol
Lincosides
What are the narrow spectrum penicillinase-resistant penicillins?
Dicloxacillin Oxacillin Nafcillin Methicillin
What are the 4th generation cephalosporins?
Cephepine
What are broad-spectrum penicillinase sensitive drugs?
Ampicillin Amoxicillin Pipericillin
Two categories of 30s ribosomal subunit inhibitors:
Aminoglycosides (bacteriocidal)
Tetracyclines (bacteriostatic)
Chloramphenicol:
Chloramphenicol
What are the two general bacterial protein synthesis inhibitors?
30s ribosomal subunit inhibitors 50s ribosomal subunit inhibitors
Macrolides:
Azithromycin
Clindamycin
Erythromycin
What are 4th generation cephalosporins used to treat?
Gram + cocci and gram - cocci
What are the two general categories of anti-folate drugs?
Sulfanamides
Dihydrofolate reductase inhibitors
Three types of penicillins?
Narrow spectrum - penicillinase-sensitive Narrow spectrum - penicillinase-resistant Broad spectrum - penicillinase-sensitive
How do penicillins work?
Covalently bond and inactivate penicillin bind protein (peptidase forming a cross link in the cells wall)
What are the 2nd generation cephalosporins?
Cefoxitin
What are the 3rd generation cephalosporins?
Cefteriaxone
Carbapenem antibiotic
Imipenem
Glycopeptide antibiotic:
Vancomycin
Fluoroquinolones:
Ciprofloxacin
Levofloxacin
What are non-beta-lactam cell wall inhibitors?
Miscellaneous cell wall inhibitors Glycopeptide antibiotics
What are 1st generation cephalosporins used to treat?
Gram + cocci
What are the beta-lactam (cell wall synthesis inhibitors) antibiotics?
Penicillins Cephalosporins Carbapenems Monobactams
What are the 1st generation cephalosporins?
Cephazolin
Cephalexin
Lincosides:
Clindamycin
Monobactam antibiotic:
Aztreonam
DHFR inhibitors:
TMP
Pirymethamine