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Urinary Exam 1 > Renal Tubular Transport Mechanism II > Flashcards

Renal Tubular Transport Mechanism II Flashcards

1
Q

Where does the largest amount of Na+ get reabsorbed?

A

Proximal convoluted tubule (70%)

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2
Q

Why does Na+ osmolality stay the same along the proximal tubule?

A

Water follows it wherever it goes

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3
Q

What pumps Na+ at the basolateral membrane?

A

Na+/Cl- ATPase pump

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4
Q

How does Na+ enter the apical membrane?

A

Downhill gradient

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5
Q

What is important to note about water movement in the PCT?

A

Water is reabsorbed via osmosis through aquaporins, this causes an increase in solute concentrations left behind allowing them to be reabsorbed down their gradients

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6
Q

What various ions pass via paracellular route?

A

Cl-
Ca2+
K+
Urea

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7
Q

What pumps glucose in the apical membrane?

A

SGLT2

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8
Q

What pumps glucose in the basolateral membrane?

A

GLUT2

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9
Q

What pumps HCO3- in the basolateral membrane?

A

Na+/HCO3- cotransporter

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10
Q

What way can Na+ move across the apical membrane TAL?

A

Solute symporters
Na-H exchanger
Na+ paracellular movement

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11
Q

Transepithelial electrochemical driving force in proximal tubule S1 and S3:

A

S1: -3mV
S3: +3mV
(stronger movement back in S3)

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12
Q

What does CFEX pump do?

A

Pumps chlorine in and bases out across apical membrane to tubule lumen where they are protonated and brought back into the cell

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13
Q

What does KCC pump do?

A

K+ Cl- cotransporter

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14
Q

What type of transport takes place in the thin loops of Henle?

A

Paracellular Na+

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15
Q

Where are the NKCC2 channels found?

A

Thick ascending limb

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16
Q

What does the NKCC2 do?

A

Apical membrane reabsorption of Na+/K+/2Cl-

17
Q

What diuretic inhibits NKCC2?

A

Furosemide

Bumetanide

18
Q

Where is the NCC (Na/Cl cotransporter) found?

A

Distal convoluted tubule

19
Q

What diuretics block the NCC?

A

Thiazides

20
Q

Where are ENaC receptors found?

A

Collecting tubule principal cells

21
Q

What diuretics block ENaC?

A

Amiloride

22
Q

What does ENaC do?

A

Pump Na+ across the apical membrane

23
Q

What is the major absorber of chloride in the S3 cells?

A

CFEX

24
Q

What does CFEX absorb?

A

Cl-formate/oxalate/HCO3 and OH exchanger

25
Q

What pumps Cl- across the basolateral membrane in the S3 cells?

A

CFTR

KCC (K/Cl cotransporter)

26
Q

Cl- reabsorption in the TAL apical membrane and basolateral:

A 
Apical: Na/K/Cl cotransporter
Sodium/hydrogen exchanger
Basolateral: N/K pump
Cl- channel
Cl-HCO3 exchanger
27
Q

Cl- reabsorption in the DCT apical and basolateral:

A

Apical: Sodium/Cl- (NC-cotransporter)
Basolateral: N/K pump
Chloride channel

28
Q

Cl- transport in the collecting tubule principle cell:

A

Paracellular diffusion

29
Q

Cl- transport in the collecting tubule beta-intercalated cells apical and basolateral:

A

Apical: N/HCO3- exchanger
Basolateral: Cl- channel

Urinary Exam 1 (16 decks)

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