Four Renal Autoregulators

Question 1

What does aldosterone cause?

Answer 1

Na+ and H20 absorption

Question 2

How does A2 work?

Answer 2

Binds G-proteins to cause intracellular signaling

Question 3

What does A2 cause?

Answer 3

Decreased Renin secretion
Reduced RPF
Increase GFR
Constrict mesangial cells decreasing GFR
Na+ reabsorption via Na-H exchanger in PCT

Question 4

How does aldosterone increase Na+ reabsorption?

Answer 4

Increase genetic expression of apical Na+ channels and basolateral membrane Na/K ATPase

Question 5

What does sympathetic innervation cause?

Answer 5

RAS cascade causing renin release, A2 vasoconstriction, and increase in Na+ and water reabsorption to increase pressure

Question 6

How does sympathetic cause RAS?

Answer 6

Innervates granular cells to release renin

Question 7

Two way ADH is released?

Answer 7

1. ) Baroreceptors in the atrial walls detect low BP sending afferent signals to the hypothalamus causing release of ADH
2. ) Hypothalamus osmoreceptors monitor concentration in the blood with increase osmolarity sends signals to posterior pituitary to release it

Question 8

Mechanism ADH works through?

Answer 8

V1 receptors contraction of SM decreasing GFR
V2 in principal cells causing genomic expression of AQ2 and increasing transport of AQ2 receptors to membrane in the collecting ducts

Question 9

How is ANP activated?

Answer 9

Atrial baroreceptors being stretched

Question 10

What does ANP cause?

Answer 10

Decreases resorption of Na+ leaving it in the tubule

Question 11

How does ANP work?

Answer 11

Dilates glomerular afferent arterioles, inhibits release of renin, inhibits actions of AII and acts in the medullary collecting duct to inhibit Na+ resorption