Transplant / Hairloss / OAB / Muscle relaxants

Question 1

What is induction transplant therapy?

Answer 1

Steroids, thymoglobulin/basiliximab IV at time of transplant

Question 2

Tacrolimus

Brand
ROA
Indication
Stability
ADE
Monitoring

Answer 2

Prograf, astagraf, envasus, protopic

IR/ER tabs, packets, IV , ointment

IV must be in GLASS

Nephrotox

Monitor therapeutic levels

Question 3

Cyclosporine

Brand
Indication
ROA
BBW
Monitor
Pgx

Answer 3

Gengrag, neoral, sandimmune, Cequa, restasis

Psoriasis, RA, transplant, dry eyes

Oral, IV, opthalmic

Nephrotox

Therapeutic levels

450 substrate

Question 4

Mycophenolate

Brand
ROA
BBW
Requirements

Answer 4

Cellcept Myfortic

Caps, IV - empty stomach

Infections, malignancy, pregnancy

Pregnancy test and two forms of contraceptions

Question 5

Azathioprine

Brand
Indication

Answer 5

Imuran

Transplant, RA

Question 6

Sirolimus

Brand
Indication
Contraindication
Storage
PGx

Answer 6

Rapamune

Renal transplant

Liver and lung transplants

Fridge

3A4 substrates

Question 7

Everolimus

Brand
Indication

Answer 7

Afinitor
Zortress

Transplant (zortress)

Question 8

Belatacept

Brand
Indication
ROA

Answer 8

Nulojix

Kidney transplant
PPX of organ rejection

IV

Question 9

Thymoglobulin

MOA
Induction

Answer 9

Depletes CD4 lymphocytes

Induction therapy for transplants and acute rejection

Question 10

Basiliximab

Brand
Indication

Answer 10

Simulect

Prevent acute rejection so give first dose 2 hours before surgery

Question 11

What 2 medications help with hairloss?

Answer 11

Minoxidil (Rogaine)

Finasteride 1mg (Propecia)

Question 12

What are 6 anticholinergic options for OAB + brand name ?

Answer 12

Oxybutynin (ditropan)

Darifenacin (Enablex)

Solifenacin (Vesicare)

Fesoterodine (Toviaz)

Tolterodine (detrol)

Trospium

Question 13

Mirabegron

Brand
MOa
Dose
ADE
Drug interactions
When to use

Answer 13

Myrbetriq

Beta 3 adrenergic AGONIST

25,g to 50mg PO QD

UTI, HTN, tachycardia

CYP2D6 inhibitors

When you cant use anticholinergics (BPH, glaucoma, myasthenia gravis, etc)

Question 14

Vibegron

Brand
MOA
Indication
Dose

Answer 14

Gemtesa

Beta3 adrenergic agonist

OAB

75mg PO QD

Question 15

Tizanidine

Brand
MOA
Indication
Contraindication

Answer 15

Zanaflex

Alpha 2 AGONIST

Muscle relaxants

CYP1A2 inhibitors

Question 16

Cyclobenzaprine

Brand

Answer 16

Amrix
Fexmid

Question 17

Carisoprodol

Brand
DEA class
ADE

Answer 17

Soma

C4

Hepatic and renal impairment

Question 18

Dantrolene

Brand
Indication
MOA

Answer 18

Dantrium

Spasticity, malignant hyperthermia

Interferes with Ca2+ release

Question 19

Baclofen

Brand
MOA
ROA
Max dose

Answer 19

Lioresal, Dleqsuvy

GABA-B selective agonist

PO and intrathecal

80mg/day

Question 20

Methocarbamol

Brand
Indication
ADE

Answer 20

Robaxin

MSK pain, tetanus

Urine discoloration

Question 21

Metaxaolne

Brand
Indication
Contraindication

Answer 21

Skelaxin

MSK pain

severe liver or renal impairment

Question 22

What is Addison’s disease?

What to do in a crisis?

Answer 22

Adrenal gland disorder that decreases cortisol and aldosterone production

Use IV hydrocortisone

Question 23

What is celiac’s disease?

How to test for it?

Answer 23

Autoimmune disease where ingestion of glutens leads to damage in the small intestine

IgA antibody