GERD/PUD

Question 1

What is the first line for PUD?

Answer 1

PPI

Question 2

When do you avoid use aluminum and magnesium antacids?

Answer 2

CKD because they are renally cleared

Question 3

What drugs must be separated from antacids

Answer 3

FQ’s , tetracyclines, levothyroixine , ketoconazole/itraconazole/iron (because they require acidic environment)

Question 4

Which H2RA can cause gynecomastia?

Answer 4

Cimetidine - tagament

Question 5

If GERD 1/week what do you give?

What is >1 /week?

Answer 5

H2RA

PPIC

Question 6

When to take PPI?

Which ones come IV?

What is the renal dose adjustment?

Answer 6

Before breakfast

Pantoprazole and esomeprazole

There is none

Question 7

What is the most common drug interaction with omeprazole/ esomeprazole?

Answer 7

It can decrease concentrations of clopidogrel because it is a CYP2C19 inhibitor which can prevent active formation of plavix

Question 8

What are two cytoprotective agents?

Answer 8

Misoprostol

Sucralfate

Question 9

Misoprostol

Brand
Indication
MOA
ADE

Answer 9

Cytotec

Prevention of NSAID induced ulcers and abortions

PHE1 analogue

Diarrhea, uterine bleeding

Question 10

When do you take sucralfate?

ADE?

Answer 10

Empty stomach - before meals

Constipation

Question 11

GERD in children - ages approved

Answer 11

Famotidine at any age

PPI >1 y.o
LORE - lansoprazole, omeprazole, esomeprazole, rabeprazole

Question 12

GERD in pregnancy

Answer 12

Antacids but NOT with NaHCo2 or magensium

H2RA QD

PPI if refractory

Question 13

Vonoprazan

Brand
MOA
Indication
DOse

Answer 13

Voquezna

Potassium competitive acid blocker that blocks resting and active proton pumps

erosive esophagitis

20mg QD x 8 weeks