CNS Stimulants / Weight Loss

Question 1

Methylphenidate brand names and formulations

Answer 1

Ritalin, ritalin LA, concerta (OROS), Metadate, metadate ER - PO

Methyline - Chewable tabs and oral suspension

Quillivant XR - Suspension

Daytrana - Patch `

Question 2

Atomoxetine

Brand
Indication
MOA
ADE

Answer 2

Strattera

ADHD

selective NE reuptake inhibitor

Liver injury, priapism

Question 3

Major drug and food interactions with stimulants

Answer 3

MAOI –> HTN crisis
High tyramine
TCA
Anti-HTN
Sympathomimetics
Warfarin

Question 4

Daytrana counseling

Answer 4

Worn daily for 9 hours (apply 2 hours prior to desired effect)

Will have continued effects for 3 hours after taking off

Question 5

Dexmethylphenidate

Brand / formulation

Answer 5

Focalin tabs
Focalin XR capsules

Question 6

Dextroamphetamine

Brand / indication

Answer 6

Dexedrine, procentra, zenzedi - narcolepsy

Lisdexamphetamine SR - Vyvanse - ADHD

Question 7

Adderall

Components

Answer 7

dextroamphemtamine and amphetamine mix

Question 8

Modafinil

Brand
Indications
Warnings

Answer 8

Provigil

Narcolepsy , OSA, shift work sleep disorder

Psychiatric problems, serious allergic reactions

Question 9

Viloxazine

Brand
Dose
MOA
Indication
Contraindication
PGx

Answer 9

Qelbree

100-400mg QD

Selective NE reuptake inhibitor

For ADHD 6-17 years old

Within 14D of MAOi

Is a 1A2 inhibitor

Question 10

Guanfacine

Brand
Class
ADE

Answer 10

Intuniv

Non stimulate alpha-2 agonist

Somnolence

Question 11

Clonidine ER

Brand
Class
Dose

Answer 11

Kapvay

Alpha 2 agonist

0.1mg/day titrate to max 0.4mg/day

Question 12

Phentermine

Brand
Indication
Dosing
Contraindication

Answer 12

Adipex, Lomaira

Short term (8-12 weeks) for obesity

8mg TID before meals

14 days of MAOi

Question 13

Orlistat

Brand
MIA
Dose

Answer 13

Xenical (120mg), Alli (60mg)

Gastric and pancreatic lipase inhibitor

60-120mg TID before or 1 hour after meals - only take with fatty meals

Question 14

Qsymia

Components
Dose
ADE

Answer 14

Phentermine + topiramate

3.75mg QD up to 15mg daily

Anticholinergic effects, kidney stones

Question 15

Contrave

Components
Dose
Contraindication

Answer 15

Bupropion and naltrexone

8mg BID not with high fat meal

Uncontrolled HTN, seizures, anorexia, opioid use, 14 days of MAOi

Question 16

Liraglutide

Brand
Indication
MOA
Dose
ADE

Answer 16

Saxenda

Weight loss (remember that victoza is for DM)

GLP-1

3mg SUBQ DAILY

GI upset, pancreatitis

Question 17

Semaglutide

Brand
MOA
Dose

Answer 17

Wegovy

GLP1-agonist

0.25mg SUBQ WEEKLY and increase to 2.4mg maintenance dose

Question 18

GLP1 agonist ADE

Answer 18

Gallbladder disease
weight loss
thyroid tumors
GI symptoms
Pancreatitis

Question 19

Plenity

What is it
Dose

Answer 19

Cellulose and citric acid hydrogel that forms a matrix to feel full

is considered a DEVICE not a drug

2.25g BID with 16ox of water

Question 20

What is rumination disorder

Answer 20

Bringing back food and rechewing partially digested food

Question 21

Solfiramfetol

Brand
MOA
Indication
Dose

Answer 21

Sunosi
Da and NE reuptake inhibitor

controlled for Narcolepsy and OSA

37.5 (narc) -75mg(OSA) initial and up to 150mg daily

Question 22

Pitolisant

Brand
MOA
Indication

Answer 22

Wakix

Histamine 3 receptor antagonist

Non controlled for narcolepsy

Question 23

Sodium oxybate

Brand / formulation
MOA
Indication

Answer 23

Lumryz (ER suspension), Xyrem (IR solution)

Sodium salt of GHB to activate GABA and suppress DA activity

Controlled for narcolepsy (improved sleep efficiency)