ANS Flashcards
Phentolamine
Brand
ROA
MOA
Indication
Regitine
IV/IM
Alpha blocker
Hypertensive crisis associated with pheochromocytoma, cocaine OD, or MAOI/tyramine interaction
Albuterol
MOA
Indication
Adrenergic agonist
Asthma/COPD
What is a major side effect of alpha-1 blockers?
What are some examples?
Orthostatic hypotension
Terazosin
Prazosin
Doxazosin
Tamsulosin
Dopamine
MOA
Benefit
Vasoconstricts all peripheral arteries
Vasodilates the kidneys
Norepinephrine
Brand
MOA
Problem
Levophed
A1 agonist - peripheral vasoconstrictor –> increased SVR –> increased BP
Also vasoconstricts renal arteries –> decreased blood flow to kidneys –> increased BUN/SCr = pre renal AKI
What are the three types of shock?
What is the first measure of treatment?
Hypovolemic - low circulatory volume (blood loss, dehydration, etc)
Distributive/septic - vasodilation by bacterial toxins
Cardiogenic - heart pump failure
Resuscitation by IV 0.9% NS
Where can you find each receptor:
alpha 1
alpha 2 (what’s an example?)
Beta 1
beta 2
beta 3
alpha 1 - peripheral vasculature
alpha 2 - negative feedback on presynaptic vesicle (clonidine)
Beta 1 - heart
beta 2 - lungs
beta 3 - fat cells
Epinephrine
MOA
Indication
ROA
Adrenergic agonist
Symptomatic bradycardia, anaphylaxis, vasopressor, local anesthetic
IM/IV/SC
Atropine
MOA
Indication
ADE
Anti-cholinergic
Symptomatic bradycardia, spastic GI/GU, treat exposure to cholinergic chemicals
Agitation and hyperactivity
Atrovent
MOA
Indication
Anti-cholinergic
Asthma/COPD
Scopolamine
MOA
Indication
Instructions
ADE
Anticholinergic
Motion sickness
Patch Q3D, start. 4H prior
Sedation and short term amnesia
Phyostigmine
MOA
Indication
Anticholinesterase
Treat OD of anticholinergics
Neostigmine
MOA
Indication
Anticholinesterase
Treat myasthenia gravis by increasing ACh in nicotininc receptors
Timolol
MOA
Indication
Anti-adrenergic = beta blocker
Glaucoma
Bethanechol
Brand
MOA
Indication
Urecholine
Direct cholinergic agonist
Urinary retention
