Labs Flashcards
How do the following labs change during cirrhosis?
albumin
bilirubin
ammonia
INR
Cholesterol
Down - which causes the ascites
Up - which causes jaundice
up - causes HE
down - increases bleeding
down
What labs are analyzed for the child pugh classification and what is the scale?
albumin, bilirubin, INR, ascites, encephalopathy
Class A - 5-6
Class B - 7-9
Class C - 10-15
What is the CrCl equation?
( 140 - age) x (weight in kg) / Scr x 72
Multiple 0.85 if women
What are the different weight equations?
IBW =
Men - 50 + (2.5 x every inch over 5ft)
Women - 45.5 + (2.5 x every inch over 5ft)
Adj BW - IBW + 0.4(ABW-IBW). ** use if ABW > 1.25 x IBW
What are the KDIGO stages of AKI?
Stage 1-SCr 1.5-1.9x the baseline or Scr increased by 0.3 or decrease in urine output to <0.5ml/kg/hr for 6-12 hours
Stage 2-SCr 2-2.9x the baseline or decrease in urine output to <0.5ml/kg/hr for >12 hours
Stage 3-SCr 3x the baseline or Scr increased by 4 or decrease in urine output to <0.3ml/kg/hr for 24 hours
What are the GFR stages?
> 90 - G1
60-90 - G2
45-60 - G3a
30-45 = G3b
15-30 - G4
<15 - G5/ESRD
What are treatment options for hyperphosphatemia?
Calcium ACETATE (not other formulation)
Sevelamer
Why does anemia happen in CKD/ESRD?
Because the kidney can not make erythropoietin
What is the corrected calcium equation?
Measured Calcium + 0.8(4-albumin)
How does albumin and calcium correlate?
Calcium binds albumin so if there is low albumin the calcium can appear to be falsely low
They say that for every 1 unit of change in albumin, you would correct by 0.8units of calcium
Hypercalcium
Signs/symptoms
Causes
Treatment
Stones, bones, groans, and psychaitric overtone
Increase PTH, thiazides
IV FLUSH/NS, loops
If chronic - can give calcitonin, bisphosphonates
Hypocalcemia
Causes
Signs/symptoms
Treatment (acute and chronic)
Low PTH, increase phosphate, decerased vitamin D, calcitonin, bisphosphonates, loops
Neuronal excitability (spasms, seizures)
Acute - IV calcium chloride/gluconate
Hyponatremia
Types
**Cause
**Treatment
Hypovolemic (most common)
** Causes- diuretics, vomit, diarrhea, burns
** Treatment – 0.9% NS (3% if severe)
Euvolemic
**Causes- SIADH, SSRI’s, MAOi, TCA, phenothiazines,antiepileptics, vinca alkaloids
*Treatment- Fluid restriction, ADH antagonists (conivaptan)
Hypervolemic
**Causes - CHF - cirrhosis
**Treatment - Fluid restriction
HypoK+
Causes
Treatment
vomit/diarrhea, diuretics, sweating, insulin, beta agonists
IV 10-40meq/hour
Remember that K+ and Mg2+ are best friends
Hyperkalemia
Causes
s/sx
Treatment
Low renal excretion - RAAS antagonists, K+ sparing, drospirenone
Arrhythmias (Peak T-wave)
- Stabilize heart with IV calcium
- Shift K+
** Insulin + dextrose
** Nebulized albuterol
** Sodium bicarb - Move K+ out
**Lasix
**GI cation exchange resins - sodium polysterene (kayexalate) , patiromer (veltassa) , ZS-9
**Hemodialysis
what is the ABG interpretation? and normal values
A / B / C / D / E
A - pH 7.35-7.45
B - CO2 35-45
C - O2 - 75-100
D - HCO3 21-27
E - O2 sat
Anion gap equation
what is normal?
AG = Na+ - (Cl- + HCO3)
3-11
Normal anion gap metabolic acidosis
Causes
You are losing bicarb from the body so chloride compensates by going up
High anion gap metabolic acidosis
Causes
MUDPILES
Methanol
Uremia
DKA
Paraldehydes
INH/iron
Lactic acidosis
Ethylene glycols (antifreeze) / EtOH
Salicylates
What is the DKA treatment plan?
- IVF NS 6-8L
- Regular insulin - 0.1u/kg/hr
- IV K+ 20-40meQ/hr unless hyperK+
- Add dextrose once glucose hits 200
- Add bicarb IF pH<6.9
TSH normal range and how does it fluctate with hypo/hyper thyroidism?
0.4-4.0
TSH is high with hypothyroidism
TSH is low with hyperthyroidsium
Total cholesterol equation
Normal lipid ranges
What is the best indicator of CV risk?
HDL + LDL + TG/5
TC - <200
TG - <150
HDL - 40-85
Non-HDL - most <130
LDL - patient specific
Non-HDL cholesterol
ANC equation
Normal values
WBC (in 1000’s) x ((neutrophils + bands)/1000 )
Normal ANC > 1500
<500 could indicate infection
What is polycythemia?
high RBC/HgB/Hct
Microcytic anemia causes
MCV<80
Iron deficiency
Thalassemia
Sickle cell
Lead poisioning
Normochromic normocytic anemia
MCV 80-100
ESRD
Macrocytic anemia
MCV>100
B12 deficiency
Folate deficiency