Alzheimer's Disease

Question 1

Donepezil

Brand / Formulation
MOA
Indication
Dose

Answer 1

Aricept ODT or Tabs
Adlarity - PATCH (5 or 10mg)

Cholinesterase Inhibitors

Mild to moderate and moderate to severe

mild - 5-10 mg/day
severe - 10-23 (but we never use 23)

Question 2

Rivastigmine

Brand
indication
Dose

Answer 2

Exelon

Mild-mod

1.5 up to 6mg BID with food
or
Once daily patch

Question 3

Galantamine

Brand
Indication
Dose
Warning

Answer 3

Razadyne

Mild - mod

IR - 4mg BID w/food
ER - 8mg QD in am with food

Serious skin reaction

Question 4

Cholinesterae inhibitor ADE

Answer 4

Increase gastric acid
N/V
SLUDGE
Bradycardia
May worsen asthma/COPD

Question 5

Treatment of acute toxicity of cholinesterase inhibitors

Answer 5

Atropine (anticholinergic)
0.5-1mg IV Q3-5 min

Question 6

Memantine

Brand
MOA
Indication
Formulation/dose
ADE

Answer 6

Namenda

NMDAR antagonist

Mod-severe

Tabs - 5mg up to 20mg daily
ER caps - 7,14,28mg daily
Solution

Dizziness, rash

Question 7

Namzaric

Components
Indication
Dose

Answer 7

Donepezil and memantine

Mod-severe

28mg memantine and 10mg donepezil capsule daily

Question 8

Amyvid

Components
Indication

Answer 8

Florbetapir F-18

a radioactive diagnostic agentq

Question 9

Nuedexta

Components
Indication

Answer 9

Dextromethorphan + quinidine

Psuedobulbar affect - sudden episodes of crying and laughing

Question 10

What is the scoring system for the MMSE?

Answer 10

<24 points is suggestive of dementia

Question 11

Aducanumab

Brand
Indication
MOA
Dose

Answer 11

Aduhelm

Mild AD

Anti-amyloid mAb

IV monthly

Question 12

Lecanemab

Brand
Indication
MOA
Dose

Answer 12

Leqembi

Mild AD

anti-amyloid mAb

10mg/kg (ABW) IV every 2 weeks

Question 13

Donanemab

Brand
Indication
MOA
Dose

Answer 13

Kisunia

AD

anti-amyloid mAb

700mg IV monthly x 3 doses