Transmission between neurons Flashcards
what does the depolarisation of the presynaptic membrane cause
voltage gated calcium channels to open - an influx of ca+
how is the neurotransmitter removed from the synaptic cleft
glial uptake or enzymatic degradation
what does the postsynaptic current cause on the postsynaptic membrane
excitatory or inhibitory postsynaptic potential - EPSP/IPSP
what does the neurotransmitter bind to
ion channels on the post-synaptic membrane - lock and key mechanism
what does the postsynaptic potential depend on
which ion channel is opened
what does influx of sodium + cause
depolorization
what does influx of potassium +/or chloride - cause
hyperpolarization
what are the two types of receptors and how do they differ
ionotropic - opens when molecule attaches to binding site
metabotropic - initiates a chain of reactions to open channels
Which receptor type is faster at opening channels
ionotropic
name a common neuro t and its degradation ezyme
Ach acetylcholinesterase
what does PSP stand for
post synaptic potential
Name most abundant excitatory neurotransmitter in CNS
Glutamate
most abundant inhibitory neurot in CNS
GABA
what is integration in context of neural integration
summation of PSPs in control of neuron firing
what is acetylcholine - where is it found, what does it do
neuro t found in CNA and PNS, specifically at neuromuscular junctions
what does an antagonist do
blocks the action of something
what does an agonist do
imitates the action of something - contest, struggle
what is curare and what does it do
poison that prevents muscle contraction - blocks action of ACh useful in surgery and hunting
what are monoaminies
neuro Ts, produced by neurons in the brain, G-protein coupled, excitatory/inhibitory depending on receptor type
what is dopamine
monoaminine, motor control, reward, addiction
What is serotonin
monoaminine, regulation of mood, eating, sleep, arousal and pain
