Schizophrenia and affective disporders Flashcards
what does overactivity of dopamine neurons cause
positive symptoms
what is chlorpromazine and what does it do
a dopamine antagonist - diminishes positive symptoms
an example of a dopamine agonist and what it does
amphetamine - induce positive symptoms
what is the dopamine hypothesis
more dopamine release in schz’s than controls
what did MRI scans of the brains of schz twin show
enlarged lateral ventricles in twin with schz
what is the seasonal effect
higher no. of sz births born from Jan to May
how many months after the start of the influenza epidemic was there a high number of schz births
3-6 months after start of the epidemic
what stage of pregnancy did the viral infection occur
2nd trimester
some of the minor physical abnormalities found in people with schz
wide set eyes, fine electric hair, low set ears
name main affective disorders
depression, mania, bipolar disorder, unipolar disorder
symptoms of mania
eiphoria, delusional, poor attention span, self important
what is bipolar disorder
alternating periods of mania and depression
equally frequent in men/women
what is unipolar disporder
depression without mania
2/3 times more likely in women than in men
which twin type has a higher concordance rate for affective disorders
monozygotic - 69% v 13%
what is MOA
monoamine oxidase - enzyme that destroys monoamines
