Translocations Flashcards
1
Q
t(9;22)
t(12;21)
A
Acute Lymphoblastic leukemia
2
Q
t(15;17)
A
Acute Promyelocytic leukemia (APML)
3
Q
t(9;22)
BCR-ABL fusion
increase in tyrosine kinase protein (blocks apoptosis)
A
chronic myelogenous leukemia
4
Q
t(14;18)
overexpression of BCL2
blocks apoptosis
A
follicular lymphoma
5
Q
t(11;14)
overexpression of cyclin D1
growth promotor
A
Mantle Cell Lymphoma
6
Q
C-myc translocation
growth promotor
A
Burkitt’s Lymphoma
